Synthesis of resolution of 2-arylalkyl-2-(tetrazol-5-yl)-N-arylalkyl-carboxamides. A new class of chiral sterically hindered tetrazole derivatives
Chiral, racemic 2-arylalkyl-2-(tetrazol-5-yl)-N-arylalkylcarboxamides 3 were conveniently prepared from ethyl cyanoacetate in four steps. The synthetic methodology developed is a facile way of introducing bulky substituents into a peptide-like framework,
Moriarty,Levy
p. 155 - 160
(2007/10/02)
Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest
A strategy of highly stereoselective enolate trapping of lithium (1S,2R,4R)- 10-dicyclohexylsulfamoylisobornyl-2-cyano-3,3-diphenylpropanoate combined with the appropriate rearrangement process allows the asymmetric synthesis of a novel α-methyl amino aci
Cativiela,Diaz-De-Villegas,Galvez
p. 9837 - 9846
(2007/10/02)
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