- Anti inflammatory activities of 1 cinnamoyl 2 methyl 5 methoxy 3 indolylacetic acid (cinmetacin)
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1 Cinnamoyl 2 methyl 5 methoxy 3 indolylacetic acid (cinmetacin, Indolacin), an indolylacetic acid derivative, is a new potent antiinflammatory agent with low toxicity. The antiinflammatory activities are more potent than those of oxyphenbutazone, but are considered to be about 1/4 that of indometacin on acute inflammation models. Cinmetacin, further, exhibits marked effects on chronic inflammation models (about 1/20 of indometacin). In addition, the significant analgesic and antipyretic effects equivalent to about 1/2 those of indometacin are exhibited. The most characteristic property of cinmetacin is its being markedly less toxic than indometacin. Considering from LD50 or ulcerogenic effects in rats, the present compound is 20 to 30 times more tolerable than indometacin. When therapeutic indices (ED50 in ulcerogenic effect/ED50 in carrageenin edema test) are calculated, it is concluded that cinmetacin is about 5 times safer then indometacin or oxyphenbutazone.
- Komatsu,Saito,Awata,Sakai,Inukai
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p. 1690 - 1696
(2007/10/08)
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