- Synthesis method of ertapenem monosodium salt
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The invention provides a synthesis method of an ertapenem monosodium salt. The method comprises the following steps: carrying out a reaction of a penem mother nuclear MAP and an ertapenem side chain to produce an intermediate product; and performing hydro
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Paragraph 0015-0020
(2020/02/10)
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- A double protection of the border he south cultivates the crystal and its preparation process
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The present invention relates to the technical field of pharmaceutical intermediate synthesis, particularly to the technical field of a crystal form and a preparation process of an ertapenem intermediate, particularly to a crystal form and a preparation process of double-protection ertapenem, wherein the characteristic peaks of the double-protection group ertapenem crystal form exist when the 2[theta] angle is 5.7+/-0.2 DEG, 8.6+/-0.2 DEG, 12.8+/-0.2 DEG, 14.3+/-0.2 DEG, 15.8+/-0.2 DEG, 16.7+/-0.2 DEG, and 18.0+/-0.2 DEG.
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Paragraph 0055; 0056; 0057; 0058; 0059; 0060; 0061; 0062
(2017/08/25)
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- PROCESS FOR PREPARATION OF ERTAPENEM AND SALTS THEREOF
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The present invention relates to an improved process for the preparation of Ertapenem of formula (I) and its pharmaceutically acceptable salts, or hydrates, or solvates thereof. Formulae (I):
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Page/Page column 17
(2015/06/25)
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- PROCESS TO PREPARE ERTAPENEM
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The present invention relates to a novel process for the preparation of Ertapenem of formula (I) or salt thereof.
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Page/Page column 13; 14
(2013/08/28)
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- INTERMEDIATES OF CARBAPENEM, COMPOSITIONS CONTAINING THEM AND PREPARATION METHODS THEREOF
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Intermediates of Ertapenem of formula 2a wherein Np represents (I) or (II), and P1 and P2 represent carboxyl protecting groups, and their preparation methods. Compound 2a prepared by the present methods in solid form is amorphous. Th
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Page/Page column 7-8
(2012/03/26)
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- Improved process for the preparation of carbapenem using carbapenem intermediates and recovery of carbapenem
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The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem; and provides an effective process for recovering ertapenem compounds.
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Page/Page column 9
(2011/12/03)
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- Preparation of Carbapenem Intermediate and Their Use
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The present invention relates to preparing carbapenem intermediates that are useful to produce Ertapenem, Meropenem and Doripenem.
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Page/Page column 5
(2011/12/12)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC
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The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium.
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Page/Page column 5
(2009/12/27)
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- AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC
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The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formule(I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium
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Page/Page column 8-9
(2008/12/05)
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- Practical synthesis of the new carbapenem antibiotic ertapenem sodium
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A practical synthesis for the large-scale production of the new carbapenem antibiotic, [4R,5S,6S]-3-[[(3S,5S)-5-[[(3-Carboxyphenyl)amino]carbonyl]-3- pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0] hept-2-ene-2-carboxylic aci
- Williams, J. Michael,Brands, Karel M. J.,Skerlj, Renato T.,Jobson, Ronald B.,Marchesini, George,Conrad, Karen M.,Pipik, Brenda,Savary, Kimberly A.,Tsay, Fuh-Rong,Houghton, Peter G.,Sidler, D. Richard,Dolling, Ulf-H.,DiMichele, Lisa M.,Novak, Thomas J.
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p. 7479 - 7487
(2007/10/03)
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