cas 202825-46-5, Safinamide mesylate | Articles data

Articles about 202825-46-5Total 13 be found

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Process for the preparation of Safinamide Mesylate intermediate
The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.
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(2021/02/12)

A Two Hour Synthesis of the Anti-Parkinson Drug Safinamide Methanesulfonate
The critical moment of the COVID-19 outbreak requires a real-time supply of therapeutic agents. Thus, time economy in the synthesis of biologically active compounds has become increasingly decisive. In this work, we developed a two hour synthesis of the a
Higa, Vanessa M.,Omori, Alvaro T.
p. 1433 - 1436
(2021/07/20)

PROCESS FOR PREPARING SAFINAMIDE
The present invention is related to a process for preparing safinamide and salts thereof, preferably safinamide methanesulfonate, with high yields and high enantiomeric and chemical purity without the need of using highly pure intermediates. The process o
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(2021/02/12)

Synthesis and preparation of safinamide mesylate
The invention discloses a preparation method of safinamide mesylate, which comprises the following steps: by using commercially available m-fluorobenzyl chloride and p-hydroxybenzaldehyde as initial raw materials, carrying out three-step synthesis in an o
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(2020/10/04)

PROCESS FOR THE PREPARATION OF (S)-2-[[4-[(3-FLUOROPHENYL)METHOXY]PHENYL]METHYL]AMINO PROPANAMIDE METHANESULFONATE
The present invention relates to an improved process for the preparation of (S)-2- [[4-[(3-fluorophenyl) methoxy] phenyl] methyl] amino propanamide methanesulfonate compound of formula-1a, represented by the following structural formula: Formula-1a The pr
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(2019/09/18)

Safinamide mesylate preparation method
The present invention belongs to the field of pharmaceutical synthesis, and provides a new safinamide mesylate preparation method. According to the present invention, m-fluorobenzyl chloride and p-hydroxybenzaldehyde are adopted as starting raw materials,
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(2017/05/03)

Method for preparing industrial safinamide mesylate
The invention relates to a method for preparing industrial safinamide mesylate, and belongs to the technical field of organic synthesis. The method comprises the steps that a compound 3-fluorobenzylchloride and a compound p-hydroxy benzaldehyde react to g
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(2017/06/15)

Preparation method of safinamide mesilate A1 crystal form
The invention relates to a preparation method of safinamide mesilate A1 crystal form. The preparation method comprises following steps: methane sulfonic acid is reacted with safinamide at a certain temperature, cooling is carried out, and an obtained reac
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Paragraph 0055

(2017/02/24)

New crystal form of safinamide mesylate and preparation method of new crystal form
The invention discloses a new crystal form of safinamide mesylate and a preparation method of the new crystal form. According to the new crystal form, the solubility and the stability of existing products are improved, preparation and utilization of the p
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Page/Page column 0038; 0039

(2018/02/04)

A new enantioselective synthesis of the anti-Parkinson agent safinamide
An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues. Georg Thieme Verlag Stuttgart New York.
Reddi, Anjaneyulu,Mujahid, Mohammad,Sasikumar, Murugesan,Muthukrishnan, Murugan
p. 1751 - 1756
(2014/07/08)

AN IMPROVED SYNTHESIS OF ANTI-PARKINSON AGENT
The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R1 and R2 are each independently selected from hydrogen or halogen.
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(2014/11/13)

PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE
A process for obtaining therapeutically active 2-[4-(3- and 2-(flurobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower
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Page/Page column 67-68

(2009/07/17)

PROCESS FOR THE PRODUCTION OF 2- [4 - ( 3- AND 2-FLU0R0BENZYL0XY) BENZYLAMIN0] PROPAN AMIDES
A process for obtaining therapeutically active 2-[4-(3- and 2- (fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower
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(2008/06/13)

Chemical Properties

Melting Point: 210° (dec)
Boiling Point: 476.7°Cat760mmHg
Flash Point:242.1°C
Density: g/cm³
Solubility:H2O: ≥15mg/mL
Storage Temp.:2-8°C
Vapor Pressure: 2.98E-09mmHg at 25°C
PSA: 127.10000
LogP: 4.04410

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202825-46-5

Articles about 202825-46-5Total 13 be found

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Chemical Properties

Melting Point: 210° (dec)

Boiling Point: 476.7°Cat760mmHg

Flash Point:242.1°C

Density: g/cm³

Solubility:H2O: ≥15mg/mL

Storage Temp.:2-8°C

Vapor Pressure: 2.98E-09mmHg at 25°C

PSA: 127.10000

LogP: 4.04410

Global suppliers and manufacturers of 202825-46-5total 105 suppliers on LookChem

Article Database

202825-46-5

Articles about 202825-46-5Total 13 be found

More Articles about upstream products of 202825-46-5

Chemical Properties

Melting Point: 210° (dec)

Boiling Point: 476.7°Cat760mmHg

Flash Point:242.1°C

Density: g/cm3

Solubility:H2O: ≥15mg/mL

Storage Temp.:2-8°C

Vapor Pressure: 2.98E-09mmHg at 25°C

PSA: 127.10000

LogP: 4.04410

Global suppliers and manufacturers of 202825-46-5total 105 suppliers on LookChem

Density: g/cm³