cas 20311-78-8, enanthotoxin | Articles data ｜lookchem

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20311-78-8

Articles about 20311-78-8Total 1 be found

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Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues
We developed a synthetic scheme for the synthesis of naturally occurring (14R)-oenanthotoxin and several analogs. Key-steps of this synthesis were an efficient homo-coupling of alkynes and a chemoenzymatic resolution of racemic oenanthotoxin using novozyme 435 and vinyl acetate. The compounds were screened for their cytotoxic activity using a photometric sulforhodamine B assays and several human tumor cell lines. Oenanthotoxin and many derivatives thereof were cytotoxic to tumor cell lines as well as to non-malignant mouse fibroblasts. The highest activity was determined for human ovarian cancer cells A2780 with EC50 = 3.8 μM.
Sommerwerk, Sven,Heller, Lucie,Siewert, Bianka,Csuk, René
p. 5595 - 5602
(2015/11/11)

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Chemical Properties

Melting Point: 87° (natural), 68° (synthetic)
Boiling Point: 458.7°C at 760 mmHg
Flash Point:213.8°C
Density: 1.025g/cm³
Vapor Pressure: 2.42E-10mmHg at 25°C
Refractive Index: 1.4770 (estimate)
PSA: 40.46000
LogP: 2.59530

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