- An efficient domino Sonogashira/double carbopalladation/C-H-activation reaction leading to fluorescent polycyclic aromatic hydrocarbons
-
A facile synthesis of fluorescent polycyclic aromatic hydrocarbons through a highly productive palladium-catalyzed fourfold domino Sonogashira/double carbopalladation/C-H-activation process was developed.
- Tietze, Lutz F.,Eichhorst, Christoph
-
-
Read Online
- Acid-catalysed selective monoiodination of electron-rich arenes by alkali metal iodides
-
The reaction of electron-rich arenes with alkali metal iodides such as sodium and potassium iodides in the presence of cone. H2SO 4 gives p-iodoarenes in high yields.
- Pasha,Myint, Yi Yi
-
-
Read Online
- Gold-Catalyzed Atroposelective Synthesis of 1,1′-Binaphthalene-2,3′-diols
-
A highly atroposelective (up to 97 % ee) Au-catalyzed synthesis of 1,1′-binaphthalene-2,3′-diols is reported starting from a range of substituted benzyl alkynones. Essential for the achievement of high enantioselectivity during the key assembly of the nap
- Alcarazo, Manuel,Golz, Christopher,Simon, Martin,Zhang, Jianwei
-
-
Read Online
- Synthesis and stereochemical behavior of a new chiral oxa[7]heterohelicene
-
A new chiral oxa[7]heterohelicene 1b was synthesized by catalytic aerobic-oxidative tandem cyclization of the o-phenylene-linked bis(2-naphthol) derivative 3 with palladium acetate in dimethyl sulfoxide. Optical resolution of 1b was possible on chiral HPLC, but it was found stereochemically rather unstable at ambient temperature. Kinetic analysis and DFT calculation for the dynamics of racemization of 1b were also disclosed.
- Irie, Ryo,Tanoue, Akihiro,Urakawa, Suguru,Imahori, Tatsushi,Igawa, Kazunobu,Matsumoto, Taisuke,Tomooka, Katsuhiko,Kikuta, Shinsuke,Uchida, Tatsuya,Katsuki, Tsutomu
-
-
Read Online
- Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C?H Halogenation
-
A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and dimethyl sulfoxide (DMSO) for C?H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur
- Dalai, Pallaba Ganjan,Palit, Kuntal,Panda, Niranjan
-
supporting information
p. 1031 - 1038
(2022/02/02)
-
- Dearomatization/Deiodination of o-Iodophenolic Compounds with α,β-Unsaturated Imines for Accessing Benzofuran Derivatives
-
A dearomatization/deiodination/rearomatization strategy for the [3 + 2] cyclization of o-iodophenolic substrates with α,β-unsaturated imines to construct various dihydrobenzofuran-related skeletons has been established. Tolerance to different functional g
- Luan, Xinjun,Yu, Jingxun,Yuan, Zhiwei,Zhou, Bigui
-
supporting information
p. 837 - 841
(2022/02/07)
-
- Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes
-
Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.
- Lin, Yan,Jin, Jun,Wang, Chaoli,Wan, Jie-Ping,Liu, Yunyun
-
p. 12378 - 12385
(2021/09/07)
-
- TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND
-
Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
- -
-
Paragraph 0090-0091
(2021/07/17)
-
- Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements
-
An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20?:?1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.
- Qu, Jingping,Wang, Baomin,Wang, Wenyao,Wei, Shiqiang,Zhang, Wande
-
supporting information
p. 6550 - 6553
(2021/07/07)
-
- Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines
-
We present an unprecedented atroposelective [8+2] cycloaddition reaction between pyridinium/isoquinolinium ylides and ynals. It is worth noting that this protocol represents a new example of the organocatalyzed atropoenantioselective higher-order cycloaddition reaction, providing various axial chiral 3-arylindolizines in good yields and high enantioselectivities. In addition, the obtained axially chiral 3-aryldolizines also provide many opportunities for structural transformations and potential drug discovery.
- Yang, Gongming,Li, Zhipeng,Liu, Yuhan,Guo, Donghui,Sheng, Xijun,Wang, Jian
-
supporting information
p. 8109 - 8113
(2021/10/20)
-
- A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds
-
Tiacumicin B (also known as fidaxomicin or difimicin) is a marketed 18-membered macrolide antibiotic for the treatment of Clostridium difficile infections. Tiacumicin B is structurally characterized with two chlorine atoms substituted on the aromatic ring
- Zhang, Haibo,Zhang, Liping,Khan, Imran,Zhang, Guangtao,Zhu, Yiguang,Zhang, Changsheng
-
p. 1736 - 1742
(2021/09/09)
-
- SMALL MOLECULE INHIBITORS OF A PROTEIN COMPLEX
-
Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.
- -
-
Paragraph 00155
(2020/12/29)
-
- Br?nsted Acid-Catalyzed Enantioselective Cycloisomerization of Arylalkynes
-
The first example of an enantioselective carbocyclization of an alkyne-containing substrate catalyzed by chiral Br?nsted acids was achieved. The use of the 2-hydroxynaphthyl substituent on the alkyne as a directing group constituted the key parameter enabling both efficient regioselective protonation of the carbon–carbon triple bond and chiral induction. The key cationic intermediate could be depicted either as a cationic vinylidene ortho-quinone methide or a stabilized vinyl cation. Atropoisomeric phenanthrenes derivatives were produced in high yields and good enantioselectivities under mild, metal-free reaction conditions in the presence of chiral N-triflylphosphoramide catalysts. The carbenic nature of the cationic intermediate was also exploited to describe an example of alkyne/alkane cycloisomerization.
- Abadie, Baptiste,Berlande, Murielle,Dhara, Kalyan,Gicquiaud, Julien,Hermange, Philippe,Sotiropoulos, Jean-Marc,Toullec, Patrick Y.
-
supporting information
p. 16266 - 16271
(2020/11/30)
-
- Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols
-
An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.
- Satkar, Yuvraj,Yera-Ledesma, Luisa F.,Mali, Narendra,Patil, Dipak,Segura-Quezada, Luis A.,Ramírez-Morales, Perla I.,Solorio-Alvarado, César R.,Navarro-Santos, Pedro
-
p. 4149 - 4164
(2019/04/30)
-
- Metal-free difunctionalization of alkynes to access tetrasubstituted olefins through spontaneous selenosulfonylation of vinylidene: Ortho -quinone methide (VQM)
-
A metal-free difunctionalization of alkynes to access tetrasubstituted olefins through spontaneous selenosulfonylation of vinylidene ortho-quinone methide (VQM) was described herein. The reaction was conducted under mild conditions without any catalysts or additives. Preliminary mechanism studies revealed that the formation of VQM was the key for this alkyne di-functionalization reaction. The reaction could be applied in the enantioselective asymmetric synthesis of axially chiral styrene. Furthermore, the selenosulfonylation adducts can be transformed into useful naphtho[2,1-b]furan and benzofuran scaffolds.
- Huang, Shengli,Chen, Zhili,Mao, Hui,Hu, Fangli,Li, Dongmei,Tan, Yu,Yang, Fengqing,Qin, Wenling
-
supporting information
p. 1121 - 1129
(2019/02/07)
-
- Electrochemical Oxidative C(sp2)–H Bond Selenylation of Activated Arenes
-
Herein, we report an electrochemical oxidative C(sp2)–H selenylation of activated arenes. The reaction proceeds in an undivided electrochemical cell at Pt-electrodes in the presence of KI as the supporting electrolyte, which could suffer oxidat
- Meirinho, Anne G.,Pereira, Vinícius F.,Martins, Guilherme M.,Saba, Sumbal,Rafique, Jamal,Braga, Antonio L.,Mendes, Samuel R.
-
supporting information
p. 6465 - 6469
(2019/08/21)
-
- EBINOL axial chiral compound as well as synthesis method and application thereof
-
The invention belongs to the field of axial chiral compounds, and discloses an EBINOL axial chiral compound. The EBINOL axial chiral compound has the following general formula(the formula is shown inthe description), wherein R and R are respectively
- -
-
Paragraph 0075-0078
(2019/08/02)
-
- Iodine-Mediated Synthesis of Methylthio-Substituted Catechols from Cyclohexanones
-
A novel and efficient I2-mediated direct synthesis of methylthio-substituted catechols from cyclohexanones was developed. Various cyclohexanones underwent oxygenation, methylthiolation, and dehydrogenative aromatization in one pot to form the desired products in moderate to good yields. DMSO was utilized as the solvent, oxygen source, and methylthiolation agent. A possible reaction mechanism is proposed. (Figure presented.).
- Wu, Yue-Hua,Wang, Nai-Xing,Zhang, Tong,Yan, Zhan,Xu, Bao-Cai,Inoa, Joan,Xing, Yalan
-
supporting information
p. 3008 - 3013
(2019/04/30)
-
- Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes
-
We describe herein an organocatalytic enantioselective approach for the construction of axially chiral sulfone-containing styrenes. Various axially chiral sulfone-containing styrene compounds were prepared with excellent enantioselectivities (up to >99% ee) and almost complete E/Z selectivities (>99% E/Z). Furthermore, the axially chiral sulfone-containing styrenes could be easily converted into phosphonic acid and S/P ligands, which could be potentially used as organocatalysts or ligands in asymmetric catalysis.
- Jia, Shiqi,Chen, Zhili,Zhang, Nan,Tan, Yu,Liu, Yidong,Deng, Jun,Yan, Hailong
-
supporting information
p. 7056 - 7060
(2018/05/30)
-
- Method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction
-
The invention discloses a method for synthesizing mono-aryl iodide or di-aryl iodide based on aromatic hydrocarbon carboxylic acid decarboxylic reaction. The method is characterized in that under a protective atmosphere, carrying out one-pot reaction on a
- -
-
Paragraph 0067; 0068
(2017/07/23)
-
- A highly efficient metal-free approach to: Meta - And multiple-substituted phenols via a simple oxidation of cyclohexenones
-
A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.
- Liang, Yu-Feng,Song, Song,Ai, Lingsheng,Li, Xinwei,Jiao, Ning
-
supporting information
p. 6462 - 6467
(2018/06/08)
-
- Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization
-
An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.
- Song, Song,Sun, Xiang,Li, Xinwei,Yuan, Yizhi,Jiao, Ning
-
supporting information
p. 2886 - 2889
(2015/06/30)
-
- An approach to the synthesis of naphtho[b]furans from allyl bromonaphthyl ethers employing sequential photoinduced radical cyclization and dehydrohalogenation reactions
-
A simple method has been developed for the efficient synthesis of naphtho[b]furans from allyl bromonaphthyl ethers. The approach utilizes a novel photochemical process involving sequential radical cyclization and dehydrohalogenation. Because light is a readily available, environmentally friendly reagent that produces no by-products, the new process serves as a green synthetic method.
- Suzuki, Yusuke,Okita, Yoshiki,Morita, Toshio,Yoshimi, Yasuharu
-
supporting information
p. 3355 - 3357
(2014/06/09)
-
- Efficient synthesis of helical tetrasubstituted alkenes as potential molecular switches: A two-component palladium-catalyzed triple domino process
-
Fast and easy: Various helical tetrasubstituted alkenes were synthesized by a palladium-catalyzed domino process. The domino process consists of a Sonogashira reaction, a carbopalladation, and a direct C-H functionalization. Copyright
- Tietze, Lutz F.,Hungerland, Tim,Eichhorst, Christoph,Duefert, Alexander,Maass, Christian,Stalke, Dietmar
-
supporting information
p. 3668 - 3671
(2013/05/08)
-
- Synthesis of α,α-diaryl nitriles by radical nucleophilic substitution
-
The present study shows that the anion of 2-naphthylacetonitrile is substituted selectively at its Cα by aromatic halides, through a radical nucleophilic substitution mechanism, to give the corresponding α,α-diaryl nitriles in good yields. The regioselectivity of this ambident nucleophile changes with the steric hindrance at the radical centre from the aromatic substrate. The selectivity observed was investigated through a computational model of the key reaction step. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.
- Tempesti, Tomas C.,Pierini, Adriana B.,Baumgartner, Maria T.
-
body text
p. 597 - 602
(2012/04/18)
-
- Synthesis and photochemical investigations of tetrasubstituted alkenes as molecular switches-the effect of substituents
-
Molecular switches based on helical tetrasubstituted alkenes, substituted with either electron-withdrawing (CF3, F, CN; 2 a-c, 3 a,c) or -donating substituents (Me, OMe; 2 d,e), have been synthesized from acyclic precursors 4 and 5 in a domino carbopalladation/Stille reaction. This palladium-catalyzed process allowed the rapid assembly of two C-C bonds, two six-membered rings, and the tetrasubstituted double bond in a completely diastereoselective fashion. The electronic effects of the substituents on the overall switching process were investigated by alternating irradiation of two different wavelength regions. Although the substituents had only a small influence on the absorption maxima, drastic differences in the switching behavior were observed. Copyright
- Tietze, Lutz F.,Duefert, M. Alexander,Hungerland, Tim,Oum, Kawon,Lenzer, Thomas
-
supporting information; experimental part
p. 8452 - 8461
(2011/08/22)
-
- Efficient iodination of aromatic compounds using potassium ferrate supported on montmorillonite
-
Potassium ferrate impregnated on montmorillonite is a mild, cheap, and non-toxic reagent for the iodination of phenols, including naphthol, aromatic amines, and heterocyclic substrates in fair to excellent yields by a simple isolation procedure.
- Keipour, Hoda,Khalilzadeh, Mohammad A.,Mohtat, Bita,Hosseini, Abolfazl,Zareyee, Daryoush
-
experimental part
p. 1427 - 1430
(2012/06/01)
-
- Green and efficient method for the iodination of phenols in water
-
In this article, green conversion of phenols to the corresponding iodide derivatives is reported. The reactions were conducted in water, using potassium iodide as the source of iodine and potassium ferrate as the oxidizing agent. The selected phenols were successfully iodinated in good to excellent yields in mild and non-toxic reaction conditions. Copyright Taylor & Francis Group, LLC.
- Tajik, Hassan,Dadras, Akbar,Hosseini, Abolfazl
-
experimental part
p. 258 - 261
(2011/06/26)
-
- Ecofriendly iodination of activated aromatics and coumarins using potassium iodide and ammonium peroxodisulfate
-
An environmentally benign protocol for the iodination of activated aromatics, such as phenols, anilines, and hydroxycou-marins, using inexpensive commercially available potassium iodide and ammonium peroxodisulfate (1:2.5 molar equivalents per mole of substrate) in aqueous methanol (MeOH-H 2O, 6:1) at room temperature has been developed. The protocol provides for ortho-selective monoiodination as the predominant product without added acid and it is compatible with a number of common oxidizible functional groups, such as formyl, benzylic C-H, aromatic amines and hydroxymethyl. Good to acceptable yields of monoiodinated products in acceptable reaction times and exclusive ortho-iodination for 7-hydroxycoumarins, despite the presence of vinylogous electronrich C3, are some of the key advantageous features of the method. Georg Thieme Verlag Stuttgart.
- Ganguly, Nemai C.,Barik, Sujoy Kumar,Dutta, Sanjoy
-
experimental part
p. 1467 - 1472
(2010/09/16)
-
- Peroxide/potassium iodide redox systems for in situ oxyiodination of organic compounds under liquid-phase and solvent-free conditions
-
Iodination of certain aromatic amines and phenols are triggered by the oxidation of KI by peroxy compounds such as tert-butyl hydroperoxide ( tBuOOH) under liquid-phase and solvent-free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding iodo derivatives in good yield with high regioselectivity (Table 1).
- Venkateshwarlu, Gattu,Premalatha, Akarapu,Chakradhar, Anuganti,Rajanna, Kamatala Chinna,Prakash, Pondichery Kuppuswamy Sai
-
experimental part
p. 345 - 349
(2010/05/15)
-
- A practical iodination of aromatic compounds by using iodine and iodic acid
-
This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product. Copyright Taylor & Francis Group, LLC.
- Shinde, Avinash T.,Zangade, Sainath B.,Chavan, Shivaji B.,Vibhute, Archana Y.,Nalwar, Yogesh S.,Vibhute, Yeshwant B.
-
experimental part
p. 3506 - 3513
(2011/02/22)
-
- Regiospecific oxyhalogenation of aromatics over SBA-15-supported nanoparticle group IV-VI metal oxides
-
TiOx, VOx, MoOx and WOx supported on SBA-15 exhibit efficient catalytic activity for oxyhalogenation of aromatics with the H2O2-halide ion system. Unlike the hitherto known solid catalysts, these reusable catalysts yield the para-halogenated product with 100% selectivity at 298 K and moderate acidic pH (3-5). The catalytic activity was enhanced by five orders of magnitude when supported on SBA-15. Springer Science+Business Media, LLC 2010.
- Saikia,Rajesh,Srinivas,Ratnasamy
-
scheme or table
p. 190 - 201
(2010/11/05)
-
- Regioselective iodination of phenol and analogues using N-iodosuccinimide and p-toluenesulfonic acid
-
Mild and highly regioselective monoiodination of phenol and analogues is achieved in high to excellent yields at room temperature with a combination of stoichiometric p-toluenesulfonic acid and N-iodosuccinimide.
- Bovonsombat, Pakorn,Leykajarakul, Juthamard,Khan, Chiraphorn,Pla-on, Kawin,Krause, Michael M.,Khanthapura, Pratheep,Ali, Rameez,Doowa, Niran
-
scheme or table
p. 2664 - 2667
(2009/08/09)
-
- IBX-I2 redox couple for facile generation of IOH and I +: Expedient protocol for iodohydroxylation of olefins and iodination of aromatics
-
(Chemical Equation Presented) IBX is readily reduced to IBAin the presence of molecular iodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, β-unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.
- Moorthy, Jarugu Narasimha,Senapati, Kalyan,Kumar, Sarvesh
-
supporting information; experimental part
p. 6287 - 6290
(2009/12/08)
-
- Mild and efficient iodination of aromatic and heterocyclic compounds with the NaClO2/NaI/HCl system
-
NaClO2/NaI in the presence of HCl is a mild, cheap, and non-toxic reagent for the iodination of phenols, including estradiol and naphthol, aromatic amines, and heterocyclic substrates, e.g., indoles, 8-hydroxyquinoline, imidazole, in fair to excellent yields by a very simple isolation protocol. The scope of the procedure is exemplified by the first iodination of 5-nitroindole to 3-iodo-5-nitroindole in 75% yield.
- Lista, Liliana,Pezzella, Alessandro,Napolitano, Alessandra,d'Ischia, Marco
-
p. 234 - 239
(2008/09/16)
-
- Aerobic oxidative iodination of organic molecules activated by sodium nitrite
-
Aerobic oxidative iodination activated by sodium nitrite occurs effectively and selectively with 100% iodine atom economy with air as the oxidant. Silica-supported sulfuric acid was used for the activation of the catalyst and iodination. Thus, I2/NaNO2/air/silica-supported H2SO4 in acetonitrile iodinated aromatics, ketones and aldehydes effectively at ambient temperature.
- Iskra, Jernej,Stavber, Stojan,Zupan, Marko
-
p. 893 - 895
(2008/09/17)
-
- Room-temperature Suzuki-Miyaura couplings in water facilitated by nonionic amphiphiles
-
(Chemical Equation Presented) Use of a dilute aqueous solution containing a nonionic amphiphile allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.
- Lipshutz, Bruce H.,Petersen, Tue B.,Abela, Alexander R.
-
supporting information; experimental part
p. 1333 - 1336
(2009/04/12)
-
- Regioselective iodination of arenes using iodine/NaBO3· 4H2O system in ionic liquid
-
A mild, efficient, and simple protocol was developed for iodination of arenes and heterocyclic compounds with molecular iodine catalyzed by sodium perborate in ionic liquid. The methodology offered iodoarenes in good to excellent yields at room temperature. The protocol proved to be highly selective, as a single isomer was formed exclusively in most of the substrates. Copyright Taylor & Francis Group, LLC.
- Bhilare, Sachin V.,Deorukhkar, Amol R.,Darvatkar, Nitin B.,Salunkhe, Manikrao M.
-
p. 2881 - 2888
(2008/12/22)
-
- A green reagent for the iodination of phenols
-
A new reagent (I2/NaNO2) for the iodination of the aromatic ring of phenols has been discovered. The reaction proceeds at room temperature in 1.5-6 hours. In the presence of this reagent, iodinated compounds are regioselectively formed in significant yields from the corresponding substrates. Georg Thieme Verlag Stuttgart.
- Kiran,Konakahara, Takeo,Sakai, Norio
-
experimental part
p. 2327 - 2332
(2009/04/04)
-
- LEWIS ACID CATALYZED HALOGENATION OF ACTIVATED CARBON ATOMS
-
A practical and efficient method for halogenation of activated carbon atoms using readily available /V-haloimides and a Lewis acid catalyst has been disclosed. This methodology is applicable to a range of compounds and any halogen atom can be directly introduced to the substrate. The mild reaction conditions, easy workup procedure and simple operation make this method valuable from both an environmental and preparative point of view.
- -
-
Page/Page column 26-27
(2008/06/13)
-
- A convenient procedure for the iodination of arenes
-
Two different procedures for the iodination of various arenes using potassium bromate and potassium iodide in the presence of hydrochloric acid are presented. Iodination of benzene, naphthalene and deactivated arenes were carried out in aqueous acetic acid medium and good yields of iodoarenes were obtained. Activated arenes, such as anisole, substituted phenols and anilines underwent excellent conversion to their iodinated products in an aqueous methanol medium.
- Sathiyapriya,Karunakaran, R. Joel
-
p. 575 - 576
(2007/10/03)
-
- Novel, water-based procedure for the mono iodination of aromatic amines and phenols
-
A mixture of potassium chlorate and potassium iodide was found to be a good iodinating agent for various aromatic amines and phenols with excellent yields in the presence of mineral acid in aqueous medium. Copyright Taylor & Francis Group, LLC.
- Sathiyapriya,Joel Karunakaran
-
p. 1915 - 1917
(2007/10/03)
-
- Diatomite-supported Pd nanoparticles: An efficient catalyst for Heck and Suzuki reactions
-
The Pd nanoparticles immobilized on natural diatomite were achieved by a simple procedure. The catalysts are highly active for Heck and Suzuki reactions and can be recovered and reused many times. The catalytic process was also investigated.
- Zhang, Zuhui,Wang, Zhiyong
-
p. 7485 - 7487
(2007/10/03)
-
- Lewis acid catalyzed highly selective halogenation of aromatic compounds
-
A simple and efficient procedure for the halogenation of aromatic compounds with NCS, NBS, NIS and NFSI in the presence of catalytic amount of ZrCl 4 is described. Chlorination, bromination, iodination and fluorination of various aromatic compounds are performed with high selectivity under mild reaction conditions. Georg Thieme Verlag Stuttgart.
- Zhang, Yanhua,Shibatomi, Kazutaka,Yamamoto, Hisashi
-
p. 2837 - 2842
(2007/10/03)
-
- Nonmetal-catalyzed iodination of arenes with iodide and hydrogen peroxide
-
Oxidative iodination of arenes was carried out with one equivalent of KI and two equivalents of 30% hydrogen peroxide in MeOH in the presence of strong acid. Reactions of various substituted anisoles, phenols and anilines, as well as mesitylene and uracil, were selective and effective with very good yields of isolated halogenated aromatic molecules.
- Iskra, Jernej,Stavber, Stojan,Zupan, Marko
-
p. 1869 - 1873
(2007/10/03)
-
- Highly selective iodination of phenols using potassium iodide and benzyltriphenylphosphonium peroxymonosulfate
-
An easy and selective method for monoiodination of phenols using potassium iodide in the presence of benzyltriphenylphosphonium peroxymonosulfate is presented. The reactions have been carried out in acetonitrile to afford the corresponding iodophenols in
- Hajipour, Abdol Reza,Adibi, Hadi
-
p. 294 - 295
(2007/10/03)
-
- The metal complex and homochiral diphosphines
-
Novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes, and the diphosphino-metallic complexes containing said chiral diphosphines (R) or (S), and the use of the diphosphino-metallic com
- -
-
-
- Selective para-iodination of methoxyarenes, phenols, and anilines with iodine in the presence of poly (4-vinylpyridine)-supported peroxodisulfate
-
A mild and efficient method for the direct iodination of methoxyarenes, phenols, and anilines using iodine and poly (4-vinylpyridine)-supported peroxodisulfate in acetonitrile solution, is presented. Selective para-substitution and also, the rather general applicability of this system is the advantage of the method.
- Tajik, Hassan,Mohammadpoor-Baltork, Iraj,Rasht-Abadi, Hassan Rafiee
-
p. 3579 - 3585
(2007/10/03)
-
- Efficient halogenation of aromatic systems using N-halosuccinimides in ionic liquids
-
A simple, rapid and highly regioselective green protocol has been developed for the halogenation of aromatic systems with N-halosuccinimides using room temperature ionic liquids (ILs) as novel and recyclable reaction media to produce the corresponding halogenated aromatic compounds in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times dramatically and improving the yields substantially.
- Yadav,Reddy,Reddy,Basak,Narsaiah
-
-
- A new, environment friendly protocol for iodination of electron-rich aromatic compounds
-
A new environment friendly procedure for effective aromatic iodination is presented. A mixture of potassium iodide and potassium iodate is used in the presence of an acid for in situ iodination of aromatic compounds.
- Adimurthy, Subbarayappa,Ramachandraiah, Gadde,Ghosh, Pushpito K.,Bedekar, Ashutosh V.
-
p. 5099 - 5101
(2007/10/03)
-