Synthesis of phthalimidine-3-carboxylate and benzopyrroloindolizine from N-(pyrrol-2-yl) phthalimidine-3-carboxylate
During the synthesis of the new benzo[a]pyrrolo(2,3-f)indolizine system an improved method for the synthesis of phthalimidine-3-carboxylate is reported.
A systematic study on the use of different organocatalytic activation modes for asymmetric conjugated addition reactions of isoindolinones
In this article we describe a series of new asymmetric Michael reactions of carboxylate-3-substituted isoindolinones used as nucleophiles in the synthesis of valuable chiral tetrasubstituted derivatives. It has been shown that the reactivity and enantiose
Compounds of Formula I that inhibit microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion and their uses in the treatment of diseases linked thereto in animals are described herein.
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Page/Page column 54
(2011/12/04)
Silver-catalyzed spirolactonization: first synthesis of spiroisoindole-γ-methylene-γ-butyrolactones
γ-Acetylenic carboxylic acids are cyclized to spirolactones under mild conditions, in the presence of Ag2CO3 catalyst. The corresponding spiro-5-alkylidene-γ-butyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
Rammah, Mohamed M.,Othman, Mohamed,Ciamala, Kabula,Strohmann, Carsten,Rammah, Mohamed B.
p. 3505 - 3516
(2008/09/21)
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