Alkoxyacetylenes from alkyl 1,2-dichlorovinyl ethers
Alkyl 1,2-dichlorovinyl ethers 4, prepared from sodium alkoxides 1 and trichloroethylene 2, react in tetrahydrofuran with two equivalents of butyllithium to afford lithium alkoxyacetylides 5. On the one hand, these acetylides react with ketones or dichlor
Loffler,Himbert
p. 495 - 498
(2007/10/02)
A Simple, One-Pot Synthesis of 1-Alkoxy-1-alkynes and 1-Alkoxy-1-alkyn-3-ols
The title compound are prepared by a high yield, one-pot reaction using readily available chloroacetaldehyde dialkyl acetals as starting materials.The reaction is initiated by sodium amide and the intermediate acetylide anion thus produced, reacts readily with a variety of electrophiles such as alkyl halides, carbonyl compounds or water to produce the desired products.
Stalick, Wayne M.,Hazlett, Robert N.,Morris, Robert E.
p. 287 - 290
(2007/10/02)
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