A total synthesis of (+)-quassin from naturally occurring (S)-(+)-carvone is described. The total number of steps was 28, and the overall yield was about 2.6%. The synthetic strategy for the construction of the tetracyclic carbon framework was based on a C→ABC→ABCD ring annulation sequence, involving an aldol reaction, an intramolecular Diels - Alder reaction, and an intramolecular acylation as the key steps. Subsequent functionalization of ring A and ring C then afforded the target (+)-quassin.
Shing, Tony K. M.,Jiang, Qin
p. 7059 - 7069
(2007/10/03)
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