N-heterocyclic carbene-catalyzed oxidative amidation of aldehydes with amines
The N-heterocyclic carbene (NHC)-catalyzed oxidative amidation of aromatic aldehydes with amines in the presence of N-bromosuccinimide (NBS) as an oxidant has been developed for the synthesis of amides. This amidation strategy is tolerant to both the electronic and the steric nature of the aryl aldehydes employed. The present methodology was extended to chiral amino acid derivatives to generate the corresponding amides in good yields and excellent ee values (>98%).
Alanthadka, Anitha,Maheswari, C. Uma
supporting information
p. 1199 - 1203
(2015/04/22)
Iron-catalyzed efficient synthesis of amides from aldehydes and amine hydrochloride salts
A practical and efficient method for the synthesis of amides has been developed by iron-catalysed oxidative amidation of aldehydes with amine hydrochloride salts. A wide range of amides have been obtained in good to excellent yields under mild conditions. The application of this novel amide formation reaction to the synthesis of pharmaceutical compounds has been successfully demonstrated. Copyright
Ghosh, Subhash Chandra,Ngiam, Joyce S. Y.,Chai, Christina L. L.,Seayad, Abdul M.,Dang, Tuan Thanh,Chen, Anqi
supporting information; experimental part
p. 1407 - 1412
(2012/07/13)
Synthesis and microbial hydroxylation of some azabicycloalkanes
N-Substituted 7-azabicyclo[2.2.1]heptanes have been synthesized in a short route. These compounds containing benzamide or benzenesulfonamide groups are good substrates for microbial oxidation of unactivated carbons by B. bassiana.
Olivo, Horacio F.,Hemenway, Michael S.,Gezginci, Mikail H.
p. 1309 - 1312
(2007/10/03)
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