- Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from 4,4,4-trifluoro-3-aminobutanoates
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The invention discloses a method for the preparation of substituted 6-trifluoromethylpyridine-3-carboxylic acid derivatives starting from 4,4,4-trifluoro-3-aminobutanoates and proceeding via enamines and dihydropyridinones.
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Paragraph 0047-0048
(2015/01/18)
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- METHOD FOR PREPARATION OF 6-TRIFLUOROMETHYLPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FROM TRIFLUOROACETYLACETIC ACID
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The invention discloses a method for the preparation of 6- trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and orthoesters (III), and their use for the preparation of pharmaceutical, chemical or agro-chemical products.
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Page/Page column 11
(2015/02/02)
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- Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives
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The invention discloses a method for the preparation of substituted 6-trifluoromethylpyridine-3-carboxylic acid derivatives starting from 1,1,1-trifluoroacetone or from synthetic equivalents of 1,1,1-trifluoroacetone.
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Paragraph 0043
(2014/12/09)
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- Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: Scope, tunability, and predictability
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Radical addition processes can be ideally suited for the direct functionalization of heteroaromatic bases, yet these processes are only sparsely used due to the perception of poor or unreliable control of regiochemistry. A systematic investigation of fact
- O'Hara, Fionn,Blackmond, Donna G.,Baran, Phil S.
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supporting information
p. 12122 - 12134
(2013/09/02)
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- Triazolopyridine cannabinoid receptor 1 antagonists
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The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.
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Page/Page column 78
(2008/06/13)
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- Triazolopyrimidine cannabinoid receptor 1 antagonists
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The present application describes compounds according to both Formulas I and II, pharmaceutical compositions comprising at least one compound according to either Formula I or II and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formulas I and II both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formulas: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.
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Page/Page column 42
(2010/11/25)
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- Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators
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A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.
- Lahm, George P.,Selby, Thomas P.,Freudenberger, John H.,Stevenson, Thomas M.,Myers, Brian J.,Seburyamo, Gilles,Smith, Ben K.,Flexner, Lindsey,Clark, Christopher E.,Cordova, Daniel
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p. 4898 - 4906
(2007/10/03)
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- A simple and convenient synthetic method for α -trifluoromethylpyridines
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β-Trifluoroacetylvinylamine (1) reacted easily with various active methylene compounds in the presence of trifluoroacetic acid under mild conditions to give α-trifluoromethylpyridines (2) in moderate to high yields.
- Okada, Etsuji,Kinomura, Tatsuhiko,Higashiyama, Yukio,Takeuchi, Hiroshi,Hojo, Masaru
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p. 129 - 132
(2007/10/03)
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