Pd/C-Cu in coupling-cyclization process: a general synthesis of 2-substituted 6-oxopyrrolo[3,2,1-ij]quinoline derivatives
A general and practical synthesis of 2-substituted 6-oxopyrrolo[3,2,1-ij]quinolines has been achieved following a single-step Pd/C-mediated coupling-cyclization strategy. The methodology involves the reaction of 8-iodo-4-oxo-1,4-dihydro quinoline-3-carbox
FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
The present invention relates to certain fused aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complica
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Page 259
(2008/06/13)
Palladium catalysed coupling of iodoquinolines and acetylenes - A novel entry to the pyrrolo[3,2,1-ij]-quinoline nucleus
Treatment of 4-arylamino-8-iodoquinoline derivatives with propargyl alcohol and triethylamine in the presence of iodo(phenyl)bis(triphenylphosphine) palladium and copper(I)iodide gives 6-imino-substituted pyrrolo[3,2,1-ij]quinolines under mild conditions and in moderate yields. Catalytic hydrogenation over Lindlar's catalyst affords functionalised 4H-pyrrolo[3,2,1-ij]quinolines in good yield.
Blurton, Peter,Brickwood, Angela,Dhanak, Dashyant
p. 2395 - 2403
(2007/10/03)
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