- Remote C(sp3)?H Arylation and Vinylation of N-Alkoxypyridinium Salts to δ-Aryl and δ-Vinyl Alcohols
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The reaction of readily available and bench-stable N-alkoxypyridinium salts with arylboronic and vinylboronic acids afforded δ-aryl and δ-vinyl alcohols, respectively, in the presence of fac-Ir(ppy)3 and Cu(OTf)2 dual catalysts. The reaction takes place through a domino process involving the reductive generation of alkoxyl radicals, 1,5-hydrogen atom transfer (1,5-HAT) and the copper-catalyzed cross-coupling reaction of the resulting translocated carbon radicals with boronic acids. Complementary to the Minisci reaction, this method allows for the arylation of nucleophilic alkyl radicals with both electron-rich and electron-poor arenes under mild reaction conditions.
- Bao, Xu,Wang, Qian,Zhu, Jieping
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- Direct Dehydroxylative Coupling Reaction of Alcohols with Organosilanes through Si-X Bond Activation by Halogen Bonding
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The combined use of a halogen bond (XB) donor with trimethylsilyl halide was found to be an efficient cocatalytic system for the direct dehydroxylative coupling reaction of alcohol with various nucleophiles, such as allyltrimethylsilane and trimethylcyanide, to give the corresponding adduct in moderate to excellent yields. Detailed control experiments and mechanistic studies revealed that the XB interaction was crucial for the reaction. The application of this coupling reaction is also described.
- Saito, Masato,Tsuji, Nobuya,Kobayashi, Yusuke,Takemoto, Yoshiji
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p. 3000 - 3003
(2015/06/30)
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- PREPARATION OF PHARMACEUTICAL ACTIVE INGREDIENTS USING A GLYCEROL-DERIVED SOLVENT
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A process for the preparation of pharmaceutically active ingredients is provided, wherein the reaction is carried out in glycerol formal as inert solvent. In particular, the reaction is a nucleophilic substitution. Examples of active ingredients for which this process is particularly advantageous are loperamide and pimozide. The process of the present invention allows obtaining pharmaceutically active ingredients in highly safe and non-contaminant conditions, and with fewer energetic requirements.
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Page/Page column 10-11
(2008/12/07)
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