Malonic ester amide synthesis: An efficient methodology for synthesis of amides
A general methodology malonic ester amide synthesis has been demonstrated, which uses α-substituted/unsubstituted diethyl malonates for the decarboxylative acylation of various aromatic/heteroaromatic primary/secondary amines to form one-carbon homologated amides, thus providing easy access to amides with odd/even chain lengths and an array of substituents on the alkyl/aryl part while avoiding use of acyl chlorides or peptide coupling reagents. Copyright
Mahajan, Pankaj S.,Mahajan, Jyoti P.,Mhaske, Santosh B.
p. 2508 - 2516
(2013/07/25)
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines
On the basis of the structure-activity relationship (SAR) of 4-chloro-6-nitroquipazine (Ki = 0.03 nM) and 3-fluoropropyl-6- nitroquipazine (Ki = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potenti
Byung, Seok Moon,Byoung, Se Lee,Dae, Yoon Chi
p. 4952 - 4959
(2007/10/03)
The chemistry of 5-oxodihydroisoxazoles. XX: Photolysis of 2,4-diphenylisoxazol-5(2H)-one: Evidence for singlet and triplet pathways
2,4-Diphenylisoxazol-5(2H)-one (2) has been photolysed in the presence of alcohols, amines and in inert solvents, and the products are shown to arise by two competitive singlet state photolytic processes. The minor pathway involves loss of carbon dioxide to give an imino carbene which is captured by nucleophiles: the major pathway involves isomerization to a ketene which is rapidly decarbonylated, and the resultant carbene captured by solvent. The presence of acetone or other triplet sensitizers induces a third competitive pathway involving triplet states.
Ang, Kiah H.,Prager, Rolf H.
p. 483 - 489
(2007/10/03)
3-Phenyl-4-hydroxyquinolin-2(1H)-ones: Potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex [1]
Malonamic acid derivatives as M1 selective muscarinic receptor antagonists
A series of malonamic acid esters with suitable amino alcohols, typical of antimuscarinic compounds, was synthesized and the affinities for the three pharmacologically defined muscarinic receptor subtypes, namely M1, M2 and M3/
Turconi,Banfi,Schiavi,Donetti
p. 999 - 1009
(2007/10/02)
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