Synthesis of aryl urea derivatives from aryl amines and aryl isocyanates
The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl] amino]phenoxy]-N-methylpyridine-2- carboxamide] having potential antiproliferative activity.
Usharani,Bhujanga Rao,Reddy,Dubey
p. 1802 - 1806
(2011/12/22)
Carbamate synthesis from amines and dialkyl carbonate over inexpensive and clean acidic catalyst-Sulfamic acid
Sulfamic acid has been proved to be the most efficient and recyclable catalyst in carbamate synthesis from alkylamine and dialkyl carbonate. High selectivity, cost-efficiency and simple product separation were the advantageous features obtained in this process. Sulfamic acid could be reused several times and keep its initial activity in the recycle runs. In addition, sulfamic acid has also exhibited the potential catalytic ability for alkylation of aromatic amines.
Wang, Bo,He, Jing,Sun, Run Cang
scheme or table
p. 794 - 797
(2011/11/13)
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