- Total Synthesis of the Diterpene Waihoensene
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A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is al
- Rosenbaum, Lisa-Catherine,H?fner, Maximilian,Gaich, Tanja
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supporting information
p. 2939 - 2942
(2020/12/15)
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- Synthesis of chiral seven-membered β-substituted lactams: Via Rh-catalyzed asymmetric hydrogenation
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Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).
- Huang, Yi,Li, Pan,Dong, Xiu-Qin,Zhang, Xumu
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supporting information
p. 8819 - 8823
(2018/11/30)
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- SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
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Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
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Page/Page column 46; 47
(2008/12/04)
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- PROCESS FOR PRODUCING CYCLOHEXENONE LONG-CHAIN ALCOHOLS
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A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen o
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- Mechanistic study on nitrosation-deaminocyclization of mono-carbamoylated vicinal amino alcohols and diols: a new preparative in situ formation of ethanediazo hydroxide for the ethylation of carboxylates under mild conditions
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While the cyclization of N-carbamoylamino alcohols into oxazolidinones via the activation with NO(1+) underwent smoothly, we found that similar reactions of vicinal diol monocarbamates were very slow. Mechanistic studies by means of time-resolved IR measurements of the former reaction suggested that the initial O-nitrosation was the rate-determining step. Indeed, the introduction of an ethyl group on the nitrogen terminus of diol monocarbamate promoted the desired cyclic carbonate formation. The concomitantly formed ethanediazo hydroxide, the precursor of the protonated form of diazoethane, was evidenced by trapping with p-nitrobenzoic acid as an ethyl ester. The formation of ethyl ester accelerates the reaction in an irreversible manner. Based on an elaboration of the substrates and reaction conditions, 2,3-dimethyl-2,3-butanediol mono-N-ethyl-N-nitrosocarbamate, which is easily prepared in situ from the corresponding ethylcarbamate and t-butyl nitrite, was developed as a new ethylation reagent of various carboxylic acids under mild conditions.
- Suzuki, Masumi,Sugai, Takeshi
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p. 1217 - 1228
(2007/10/03)
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- Synthesis of Mono- and Sesquiterpenoids, X. Synthesis of Sporogen-AO 1 (13-Deoxyphomenone), a Sporogenic Sesquiterpene from Aspergillus oryzae
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The total synthesis of the enantiomers of sporogen-AO 1 was achieved in 25 steps from 2,3-dimethylhydroquinone (5).Only the natural (+)-enantiomer was bioactive on Aspergillus oryzae.
- Mori, Kenji,Tamura, Hiroshi
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