NM 283, an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine
In order to improve the oral bioavailability of 2′-C-methylcytidine, a potent anti-HCV agent, the corresponding 3′-O-L-valinyl ester derivative (NM 283) has been synthesized. Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection. Copyright Taylor & Francis, Inc.
