Short synthesis of 2,4-disubstituted 1,3-oxathiolane and 1,3-dithiolane cytosine nucleosides: Facile introduction of a 4-benzoate group using benzoyl peroxide
Introduction of a benzoate group at position 4 in 2-substituted 1,3- oxathiolane and 1,3-dithiolane using benzoyl peroxide is described. The coupling reaction between 1,3-oxathiolane derivatives 3 and pyrimidine bases in the presence of TMSI produced cis