- Synthesis, crystal structures and luminescence properties of three new cadmium 3D coordination polymers
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The new rigid planar ligand 2,5-bis(3-(pyridine-4-yl)phenyl)thiazolo[5,4-d]thiazole (BPPT) has been synthesized, which is an excellent building block for assembling coordination polymer. Under solvothermal reaction conditions, cadmium ion with BPPT in the
- Ju, Hai-Yan,Zhang, Gang,Yang, Ming,Liu, De-Zheng,Yang, Yong-Sheng,Zhang, Yan-Bo
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Read Online
- 2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and uses thereof
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The invention discloses 2-(aryl (azacycloalkane-1-yl) methyl) phenol derivatives and application thereof, and belongs to the technical field of medicines. The invention provides a compound shown in a formula I or pharmaceutically acceptable salt thereof. The series of compounds have good inhibitory activity on the histone demethylase KDM4 family in vitro, the median inhibitory concentration (IC50) of most molecules on KDM4D is less than 500 nM, and the compounds have good inhibitory effect on proliferation of various human tumor cell strains in vitro, so that the series of compounds provide a new effective choice for developing targeted histone demethylase KDM4D drugs and preparing drugs for treating and/or preventing cancers and reproductive system diseases, and have good application prospects.
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Paragraph 0371-0374; 0375-0377
(2021/07/24)
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- Triazole heterocyclic compound and synthesis method thereof
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The invention discloses a triazole heterocyclic compound and a synthesis method thereof. The triazole heterocyclic compound is (Z)-N-((4H-1, 2, 4-triazole-4-yl) methylene)-3-(pyridine-4-yl) aniline, the structural formula of the triazole heterocyclic comp
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Paragraph 0024-0027
(2021/02/10)
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- ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY
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The present disclosure relates to compounds of formula I : compositions containing same and methods for treating or preventing a condition associated with brown adipose tissue dysfunction in a subject and/or for converting white adipose tissue into beige/
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Page/Page column 31
(2015/09/28)
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- INSULIN SECRETION PROMOTING AGENTS
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The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient insulin secretion such as diabetes and metabolic syndrome in a subject in need thereof.
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Page/Page column 23-24
(2013/03/26)
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- Potent small molecule Hedgehog agonists induce VEGF expression in vitro
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Here, we describe the synthesis, SAR studies as well as biological investigations of the known Hedgehog signaling agonist SAG and a small library of its analogues. The SAG and its derivatives were analyzed for their potency to activate the expression of the Hh target gene Gli1 in a reporter gene assay. By analyzing SAR important molecular descriptors for Gli1 activation have been identified. SAG as well as compound 10c proven to be potent activators of VEGF expression in cultivated dermal fibroblasts. Importantly and in contrast to SAG, derivative 10c displayed no toxicity in concentrations up to 250 μm.
- Seifert, Katrin,Buettner, Anita,Rigol, Stephan,Eilert, Nicole,Giannis, Athanassios,Wandel, Elke
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p. 6465 - 6481,17
(2012/12/11)
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- Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
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Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.
- Che, Chao,Li, Song,Yang, Bo,Xin, Shengchang,Yu, Zhixiong,Shao, Taofeng,Tao, Chuanye,Lin, Shuo,Yang, Zhen
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scheme or table
p. 841 - 849
(2012/07/28)
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- CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF
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Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. Compositions including the compounds having the formula I-A in
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- Catalysis in capillaries by Pd thin films using Microwave-Assisted Continuous-flow Organic Synthesis (MACOS)
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(Chemical Equation Presented) Finally ... metal in a microwave! Thin films of Pd black deposited onto the inner surface of microcapillaries are efficient for metal-catalyzed transformations under flow conditions including the Suzuki-Miyama and Heck couplings. The reaction mixture is flowed through these miniature capillaries while being microwaved, and conversion times are on the order of seconds.
- Shore, Gjergji,Morin, Sylvie,Organ, Michael G.
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p. 2761 - 2766
(2008/02/02)
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- Synthesis of novel palladacycles and their application in heck and Suzuki reactions under aerobic conditions
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(Chemical Equation Presented) Design and synthesis of a novel family of furancarbothioamide-based palladacycles are reported herein. These palladacycles are thermally stable, not sensitive to air or moisture, and are applied effectively in the Heck reaction of aryl halides with terminal olefins and in the Suzuki reaction of aryl halides with arylboronic acids. These reactions were performed under aerobic conditions, leading to turnover numbers (TONs) up to 1 × 105.
- Xiong, Zhengchang,Wang, Nengdong,Dai, Mingji,Li, Ang,Chen, Jiahua,Yang, Zhen
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p. 3337 - 3340
(2007/10/03)
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