- Microwave-assisted synthesis, in silico ADME prediction and antibacterial study of 2-(substituted acetamido)-5-nitrobenzophenone derivatives
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A series of novel 2-amino-5-nitrobenzophenone derivatives (3-10) were synthesized and characterized by IR, 1H NMR and CHN elemental studies. All the synthesized compounds were subjected to in silico ADME predictions for determination for drug like properties. The values of physico-chemical parameters like molecular weight, nON value, nOHNH value, n-violations and the number of rotatable bonds of all the synthesized compounds also lies between the ranges that are required for good bioavailability. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Among all the compounds synthesized compounds 4, 9, 10 have shown the maximum antibacterial activity in their group whereas compounds 3, 6, 8 have shown the minimum antibacterial activity.
- Li, Tiangang,Singh, Sandeep,Zhai, Xing,Meng, Xiangqi,Singh, Rajesh K.
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- Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7-Amino-1,3-dihydro-2H-1,4-benzodiazepin-2-one
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A variety of 1,3-dihydro-2H-1,4-benzodiazepin-2-one azomethines and 1,3-dihydro-2H-1,4-benzodiazepin-2-one benzamide were prepared, characterized and evaluated for the anticonvulsant activity in the rat using picrotoxin-induced seizure model. The prepared 1,3-dihydro-2H-1,4-benzodiazepin-2-one azomethine derivatives emerged potentially anticonvulsant molecular scaffolds exemplified by compounds, 7-{(E)-[(4-nitrophenyl)methylidene]amino}-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 7-[(E)-{[4-(dimethylamino)phenyl]methylidene}amino]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 7-{(E)-[(4-bromo-2,6-difluorophenyl)methylidene]amino}-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one and 7-[(E)-{[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}amino]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. All these four compounds have shown substantial decrease in the wet dog shake numbers and grade of convulsions with respect to the standard drug diazepam. The most active compound, 7-[(E)-{[4-(dimethylamino)phenyl]methylidene}amino]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, exhibited 74 % protection against convulsion which was higher than the standard drug diazepam. Furthermore, to identify the binding mode of the interaction amongst the target analogs and binding site of the benzodiazepine receptor, molecular docking study and molecular dynamic simulation were carried out. Additionally, in silico pharmacokinetic and toxicity predictions of target compounds were carried out using AdmetSAR tool. Results of ADMET studies suggest that the pharmacokinetic parameters of all the target compounds were within the acceptable range to become a potential drug candidate as antiepileptic agents.
- Ahamad, Tansir,Dhawale, Kiran,Gawande, Manoj B.,Ghorai, Sujit K.,Nilkanth, Pankaj R.,Sathiyanarayanan, Arulmozhi,Shelke, Sharad N.
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- Preparation method of 2-chloracetylamino-5-nitro benzophenone
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The invention provides a preparation method of 2-chloracetylamino-5-nitro benzophenone. The method comprises: taking 2-amino-5-nitro benzophenone and chloroacetyl chloride as raw materials, and performing an acylation reaction in an organic solvent for 1-3.5 h, wherein the acylation reaction is carried out in a reflux condition, the raw material ratio of 2-amino-5-nitro benzophenone to chloroacetyl chloride to the organic solvent is 50 g to (16-48.5) ml to (1000-2000) ml, and the organic solvent is a mixed solvent of cyclohexane and toluene with the volume ratio of cyclohexane to toluene being 1:1-2; and after the acylation reaction is finished, reducing the temperature to the room temperature, performing filtration, washing the obtained filter residue with water till the filter residue is neutral, and performing drying to obtain 2-chloracetylamino-5-nitro benzophenone. Compared with a preparation method in the prior art, the preparation method is reasonable in processing step design, good in operability, and less in by-products. The obtained product is high in purity and yield, and the method can meet industrial application requirements.
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Paragraph 0015; 0016; 0017; 0018; 0019
(2017/03/14)
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- Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone
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Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against Trypanosoma brucei. Main problem of the compounds is low selectivity. However, there are indications that separation of antimalarial and cytotoxic activity might by possible. In addition, some compounds inhibit human ABC transporter with nanomolar activity.
- Altenkaemper, Mirko,Bechem, Benjamin,Perruchon, Johann,Heinrich, Swetlana,Maedel, Andrea,Ortmann, Regina,Dahse, Hans-Martin,Freunscht, Ellen,Wang, Yulin,Rath, Jennifer,Stich, August,Hitzler, Manuela,Chiba, Peter,Lanzer, Michael,Schlitzer, Martin
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experimental part
p. 7690 - 7697
(2010/03/24)
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