PREPARATION OF OPTICALLY ACTIVE 1-ACETOXY-2-ARYLOXYPROPIONITRILES AND ITS APPLICATION TO A FACILE SYNTHESIS OF (S)-(-)-PROPRANOLOL
(S)-1-Acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-Propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps.
Matsuo, Noritada,Ohno, Nobuo
p. 5533 - 5534
(2007/10/02)
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