- Methods for isolating propargylated aminoindans
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Disclosed is a process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan having the structure wherein R1 is H, hydroxyl, alkoxy or wherein Y is O or S; R2 and R3 is each, independently, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl, each optionally halo substituted, or hydrogen; where the reaction mixture further comprises a solvent, a primary aminoindan having the structure wherein R1 is defined as above, and a tertiary aminoindan having the structure the process comprising d) adding an acid to the reaction mixture; e) crystallizing the mono-propargylated aminoindan under conditions suitable for the formation of a crystalline salt of the mono-propargylated aminoindan; and f) recovering the crystalline salt of the mono-propargylated aminoindan, wherein the process is performed without addition of an organic solvent. Also disclosed are the crystalline diastereomeric salts produced by the process and pharmaceutical compositions containing the salts.
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- Polymorphic forms of ladostigil tartrate
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Provided are polymorphic forms of ladostigil tartrate and methods for preparation thereof.
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- METHODS FOR PREPARATION OF LADOSTIGIL TARTRATE CRYSTALLINE FORM A1
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Provided are processes for preparing crystalline ladostigil tartrate form A1.
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- Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof
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Disclosed is crystalline ladostigil tartrate of a specified density, compositions, including pharmaceutical compositions comprising such ladostigil tartrate, and a process for the manufacture thereof.
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Page/Page column 3-4
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- Formulations of ladostigil tartrate
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Disclosed are formulations of ladostigil tartrate, including pharmaceutical compositions, process for the manufacture, and use thereof.
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Page/Page column 4
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