Isoxazolines and Isoxazoles as Factor Xa inhibitors
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.
Pruitt, James R.,Pinto, Donald J.,Estrella, Melissa J.,Bostrom, Lori L.,Knabb, Robert M.,Wong, Pancras C.,Wright, Matthew R.,Wexler, Ruth R.
p. 685 - 689
(2007/10/03)
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