The present invention relates to novel compounds of formula (I): or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay
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Page/Page column 79-80
(2008/06/13)
Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
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(2008/06/13)
New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
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(2008/06/13)
Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.
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Example 81
(2008/06/13)
Homocamptothecins: Synthesis and antitumor activity of novel E-ring- modified camptothecin analogues
Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered β-hydroxylactone which combines enhanced plasma stability and potent topoisomerase I (Topo I) mediated activity, is an attractive template for the elaboration of new anticancer a
Lavergne, Olivier,Lesueur-Ginot, Laurence,Rodas, Francesc Pla,Kasprzyk, Philip G.,Pommier, Jacques,Demarquay, Danièle,Prévost, Grégoire,Ulibarri, Gérard,Rolland, Alain,Schiano-Liberatore, Anne-Marie,Harnett, Jeremiah,Pons, Dominique,Camara, José,Bigg, Dennis C. H.
p. 5410 - 5419
(2007/10/03)
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