NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
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Page/Page column 34
(2009/10/01)
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core
The selective inhibition of coagulation factor Xa has emerged as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe highly potent benzamidine factor Xa inhibitors based on a vicinally-substituted, heterocyclic core.
Fevig, John M.,Pinto, Donald J.,Han, Qi,Quan, Mimi L.,Pruitt, James R.,Jacobson, Irina C.,Galemmo, Jr, Robert A.,Wang, Shuaige,Orwat, Michael J.,Bostrom, Lori L.,Knabb, Robert M.,Wong, Pancras C.,Lam, Patrick Y.S.,Wexler, Ruth R.
p. 641 - 645
(2007/10/03)
Nitrogen containing heteroaromatics as factor Xa inhibitors
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
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(2008/06/13)
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