- Novel E,E-diene compounds and their use as medicaments and cosmetics
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The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.
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Paragraph 0135; 0136
(2014/01/07)
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- An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide
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A nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents. The obtained nitrile oxide undergoes cycloa
- Nishiwaki, Nagatoshi,Kobiro, Kazuya,Kiyoto, Hideyuki,Hirao, Shotaro,Sawayama, Jun,Saigo, Kazuhiko,Okajima, Yoshikazu,Uehara, Toshiharu,Maki, Asaka,Ariga, Masahiro
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experimental part
p. 2832 - 2839
(2011/05/04)
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- Improved generation method for functionalized nitrile oxide
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Gentle generation of nitrile oxide bearing a carbamoyl group was performed. 4-Nitro-3-isoxazolin-5-one was treated with dipolarophiles in the mixed solvent (MeCN/H2O) at room temperature to afford cycloadducts in good yields.
- Nishiwaki, Nagatoshi,Uehara, Toshiharu,Asaka, Noriko,Tohda, Yasuo,Ariga, Masahiro,Kanemasa, Shuji
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p. 4851 - 4852
(2007/10/03)
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