Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2
Membrane transporters play a significant role in the transport of many endogenous and exogenous compounds. The knowledge of transporter substrate requirements has allowed further development of drugs that utilize them to ensure tissue permeation. In this
Obianom, Obinna N.,Coutinho, Ana L.,Yang, Wei,Yang, Hong,Xue, Fengtian,Shu, Yan
p. 2726 - 2739
(2017/08/14)
GUANIDINE COMPOUNDS AND USE THEREOF
The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
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Page/Page column 25; 54
(2015/11/09)
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