cas 211563-40-5, [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
211563-40-5

Articles about 211563-40-5Total 2 be found

Article title
Article abstract
Author
Journal number and time
Download

EFFICIENT SYNTHESIS OF A 1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
-
-
Page/Page column 16

(2010/02/11)

Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor
A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.
Pierce, Michael E.,Parsons Jr., Rodney L.,Radesca, Lilian A.,Lo, Young S.,Silverman, Stuart,Moore, James R.,Islam, Qamrul,Choudhury, Anusuya,Fortunak, Joseph M. D.,Nguyen, Dieu,Luo, Chi,Morgan, Susan J.,Davis, Wayne P.,Confalone, Pat N.,Chen, Cheng-Yi,Tillyer, Richard D.,Frey, Lisa,Tan, Lushi,Xu, Feng,Zhao, Dalian,Thompson, Andrew S.,Corley, Edward G.,Grabowski, Edward J. J.,Reamer, Robert,Reider, Paul J.
p. 8536 - 8543
(2007/10/03)

More Articles about upstream products of 211563-40-5

More Articles about downstream products of 211563-40-5

154598-52-4
efavirenz

Chemical Properties

Boiling Point: 427.446°C at 760 mmHg
Flash Point:212.312°C
Density: 1.56g/cm³
Solubility:Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.58
PKA: 9.21±0.24(Predicted)
PSA: 58.56000
LogP: 3.75460

Show more

Global suppliers and manufacturers of 211563-40-5total 9 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

BOC Sciences
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:41
Country:

Chemlyte Solutions
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:198
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

Simson Pharma Limited
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Finetech Industry Limited
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Wuxi Morality Chemical Co., Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Shenzhen Sumshine Biotech Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

NovaChemistry
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 211563-40-5

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer