Incorporation of methylated pyrimidine analogues into RNA
Routes for the preparation of 2'-silyl protected phosphoramidites of the modified nucleosides O2-methyluridine and O4-methyluridine are described. Methodology for the site-specific incorporation of these phosphonamidetes into a 25 nucleotide long oligoribonucleotide sequence by solid-phase synthesis is reported.
Vyle, Joseph S.,Young, Karen J.,Grasby, Jane A.
p. 5093 - 5096
(2007/10/03)
Synthesis of Uridine Analogues to Probe the Functional Group Requirements of the Hairpin Ribozyme
O4-Methyluridine, O2-methyluridine and 4Huridine phosphoramidites were prepared with 2'-O-silyl protection.The methyl modified pyrimidines were synthesised from uridine via the triazolide (O4-methyl) or 2,5'-cyclo derivative (O2-methyl).An improved synthesis of protected 4-thiouridine was also performed.
Vyle, Joseph S.,Young, Karen J.,Jones, Sarah,Grasby, Jane A.
p. S280 - S282
(2007/10/03)
More Articles about upstream products of 211676-84-5
Get Best Price for211676-84-51-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-4-methoxy-1H-pyrimidin-2-one