cas 21203-55-4, 2.4.6-TRIMETHYL-3-NITROPYRIDINE | Articles data ｜lookchem

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21203-55-4

Articles about 21203-55-4Total 3 be found

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As potassium channel regulator compound
The invention relates to a compound taken as a potassium channel regulator. The compound taken as the potassium channel regulator is a compound shown in a formula (I) or pharmaceutically acceptable salt thereof, and the compound or pharmaceutically accept
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Paragraph 0163; 0164; 0165

(2017/07/14)

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
Beck, James P.,Arvanitis, Argyrios G.,Curry, Matt A.,Rescinito, Joseph T.,Fitzgerald, Larry W.,Gilligan, Paul J.,Zaczek, Robert,Trainor, George L.
p. 967 - 972
(2007/10/03)

Synthesis of indoles from pyridinium salts. 7. Sterically hindered alkyl-3-nitropyridinium salts in the synthesis of indoles
The introduction of bulky alkyl substituents (iso-Pr,tert-Bu) into any positions of the starting 3-nitropyridinium salt only increases the reaction time and decreases the yields of the corresponding alkylindoles somewhat.
Yurovskaya,Afanas'ev,Druzina,Bundel'
p. 667 - 672
(2007/10/02)

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Chemical Properties

Melting Point: 35.6 °C
Boiling Point: 254.1oC at 760 mmHg
Flash Point:107.4ºC
Density: 1.159g/cm3
Storage Temp.:2-8°C
Vapor Pressure: 0.0282mmHg at 25°C
PKA: 3.29±0.18(Predicted)
PSA: 58.71000
LogP: 2.43820

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