COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES
The present disclosure relates to compounds according to Formula (I), useful for treating diseases.
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(2019/03/12)
Tuneable hydrogenation of nitriles into imines or amines with a ruthenium pincer complex under mild conditions
The selective hydrogenation of aromatic and aliphatic nitriles into amines and imines is described. Using a ruthenium pincer complex, the selectivity towards amines or imines can be controlled by simple parameter changes. The reactions are conducted under very mild conditions between 50-100°C at 0.4 MPa H2 pressure without any additives at low catalytic loadings of 0.5-1 mol %, which results in quantitative conversions and high selectivity.
The synthesis, physico-chemical, and biological characterisation of a short series of carnosine amides bearing NO-donor nitrooxy functionalities are described. The NO-donor carnosine analogues and their des-NO derivatives display carnosine-like properties