First metallation of iodo diazines. Iodo and nitrogen directed metallations. Diazines XXII
Lithiation of iodopyrazine and 4-iodo-2-methylthiopyrimidine followed by reaction with various electrophiles was successfully achieved and was used to synthesize new pyrazine and pyrimidine derivatives. Iodo and nitrogen directed metallations were observed.
Ple, Nelly,Turck, Alain,Heynderickx, Arnault,Queguiner, Guy