A Practical Telescoped Three-Step Sequence for the Preparation of (1 R,2 R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects
A large-scale, robust telescoped process involving acid chloride generation and Friedel-Crafts acylation followed by hydrolysis of an ester was developed for the manufacture of a homochiral disubstituted cyclohexane. Chromatography was avoided, and instea
Karlsson, Staffan,Bergman, Rolf,Broddefalk, Johan,L?fberg, Christian,Moore, Peter R.,Stark, Andrew,Emten?s, Hans