- METHOD FOR SYNTHESIZING COMPOUND FOR ORGANIC ELECTRONIC ELEMENT AND COMPOUND PRODUCED BY THE SAME
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The present invention relates to a method for synthesizing a compound for an organic electronic element, which provides a method for synthesizing a fluorene derivative. Provided in an embodiment of the present invention for achieving the purpose is a meth
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- Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials
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A multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.
- Fonte, Mélanie,Fagundes, Natália,Gomes, Ana,Ferraz, Ricardo,Prudêncio, Cristina,Araújo, Maria Jo?o,Gomes, Paula,Teixeira, Cátia
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p. 1166 - 1169
(2019/03/27)
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- ORGANIC ELECTRONIC ELEMENT USING A COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, AND AN ELECTRONIC DEVICE THEREOF
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Provided in the present invention are an organic electronic element using a compound which can improve light emitting efficiency, stability, and life of the element, and an electronic device thereof. The organic electronic device includes: a first electrode; a second electrode; and an organic substance layer located between the first electrode and the second electrode and including at least hole transfer layer and auxiliary light emitting layer, wherein the hole transfer layer includes a compound presented by chemical formula 1, and the auxiliary light emitting layer includes at least one among compounds presented by chemical formula 2 to 4.(110) Substrate(120) Positive electrode(130) Hole injection layer(140) Hole transfer layer(141) Buffer layer(150) Light emitting layer(151) Auxiliary light emitting layer(160) Electron transfer layer(170) Electron injection layer(180) Negative electrodeCOPYRIGHT KIPO 2015
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- Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum
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A parallel synthetic strategy to the 9-aminoacridine scaffold of the classical anti-malarial drug quinacrine (2) is presented. The method features a new route to 9-chloroacridines that utilizes triflates of salicylic acid derivatives, which are commercially available in a variety of substitution patterns. The route allows ready variation of the two diversity elements present in this class of molecules: the tricyclic aromatic heterocyclic core, and the disubstituted diamine sidechain. In this study, a library of 175 compounds was designed, although only 93 of the final products had purities acceptable for screening. Impurity was generally due to incomplete removal of 9-acridones (18), a degradation product of the 9-chloroacridine synthetic intermediates. The library was screened against two strains of Plasmodium falciparum, including a model of the drug-resistant parasite, and six novel compounds were found to have IC50 values in the low nanomolar range.
- Anderson, Marc O.,Sherrill, John,Madrid, Peter B.,Liou, Ally P.,Weisman, Jennifer L.,DeRisi, Joseph L.,Guy, R. Kiplin
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p. 334 - 343
(2007/10/03)
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- AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS
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The present invention relates to a compound formula [I] or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
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Page/Page column 128
(2010/02/07)
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