- Synthesis of metabolically blocked paclitaxel analogues
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The stereospecific syntheses of the metabolically blocked 6-α-F, Cl, Br paclitaxel, and 6-α-F-10-acetyldocetaxel are described and in vitro and in vivo activity is presented.
- Wittman, Mark D.,Altstadt, Thomas J.,Fairchild, Craig,Hansel, Stephen,Johnston, Kathy,Kadow, John F.,Long, Byron H.,Rose, William C.,Vyas, Dolatrai M.,Wu, Mu-Jen,Zoeckler, Mary E.
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p. 809 - 810
(2007/10/03)
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- Stereospecific synthesis of the major human metabolite of paclitaxel
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The stereospecific synthesis of 6-α-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-α-diol 4, obtained from paclitaxel, is converted to the 6,7-β-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd.
- Wittman, Mark D.,Kadow, John F.,Vyas, Dolatrai M.
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p. 4729 - 4731
(2007/10/03)
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