Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics
Inhibition of FBPase is considered a promising way to reduce hepatic gluconeogenesis and therefore could be a potential approach to treat type 2 diabetes. Herein we report the discovery of a series of purine phosphonic acids as AMP mimics targeting the AM
Dang, Qun,Brown, Brian S.,Liu, Yan,Rydzewski, Robert M.,Robinson, Edward D.,Van Poelje, Paul D.,Reddy, M. Rami,Erion, Mark D.
experimental part
p. 2880 - 2898
(2010/02/28)
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