The invention encompasses the pyridazin-3-one compounds of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a
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Page 36
(2010/02/07)
Pyridazinones as selective cyclooxygenase-2 inhibitors
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
Li, Chun Sing,Brideau, Christine,Chan, Chi Chung,Savoie, Chantal,Claveau, David,Charleson, Stella,Gordon, Robert,Greig, Gillian,Gauthier, Jacques Yves,Lau, Cheuk K.,Riendeau, Denis,Therien, Michel,Wong, Elizabeth,Prasit, Petpiboon
p. 597 - 600
(2007/10/03)
Pyridazinones as inhibitors of cyclooxygenase-2
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
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(2008/06/13)
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