- 6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents
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A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in LPS-induced RAW 264.7 cells with an IC50 value of 7.6 μM, and it effectively reduced the hydroxyl radical production by 50% at 100 μM in the electron spin resonance study.
- Lin, Chun-Mao,Huang, Sheng-Tung,Lee, Fu-Wei,Kuo, Hsien-Saw,Lin, Mei-Hsiang
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- Neoflavonoids as inhibitors of HIV-1 replication by targeting the Tat and NF-κB pathways
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Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were teste
- Olmedo, Dionisio A.,López-Pérez, José Luis,Del Olmo, Esther,Bedoya, Luis M.,Sancho, Rocío,Alcamí, José,Mu?oz, Eduardo,San Feliciano, Arturo,Gupta, Mahabir P.
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- Minor coumarins from Calophyllum teysmannii var. inophylloide and synthesis of cytotoxic calanone derivatives
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A chemotaxonomic survey for biologically active compounds from Malaysian Calophyllum species led to the finding of the four new benzoylcoumarins 1a, 2, 3, and 4a (including the unusual prenylated 6-benzoylcoumarin 1a, two uncommon coumarins 5 and 6a with
- Cao, Shu-Geng,Wu, Xiao-Hua,Sim, Keng-Yeow,Tan, Benny H. K.,Vittal, Jagadese J.,Pereira, Joan T.,Goh, Swee-Hock
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p. 1404 - 1416
(2007/10/03)
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