[(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
This invention provides novel 2-substituted-3-quinuclidinyl arylcarboxamides and arylthiocarboxamides and corresponding arylcarboxylates which have utility as therapeutic agents which exhibit gastric prokinetic, antiemetic, anxiolytic and 5-HT (serotonin) antagonist effects in warm blooded animals.Illustrative of an invention compound is 5-chloro-2-methoxy-4-(methylamino)-N-[2-(1-piperidinylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzamide: STR1 or a pharmaceutically acceptable salt thereof.
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(2008/06/13)
Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydroxybenzamides and thiobenzamides
This invention provides 3-quinuclidinyl benzamides which in the form of pharmaceutical compositions have utility as therapeutic agents which exhibit anxiolytic antipsychotic and cognitive improving effects in warm blooded animals. Illustrative of an invention compound is N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-4-dimethylamino-2-hydroxythiobenzamide: STR1 or a pharmaceutically acceptable salt thereof.
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(2008/06/13)
BENZOXAZINE AND BENZOXAZEPINE CARBOXAMIDE 5-HT3 ANTAGONISTS
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(2008/06/13)
SUBSTITUTED SATURATED AND UNSATURATED INDOLE QUINOLINE AND BENZAZEPINE CARBOXAMIDES AND THEIR USE AS PHARMACOLOGICAL AGENTS
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(2008/06/13)
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