Prophylactic or therapeutic agent for diseases attributable to infection with helicobacters
The present invention relates to an agent for the prophylaxis and treatment of diseases caused by Helicobacter infections, which comprises (S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxyl
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(2008/06/13)
Synthesis and structure-activity relationships of 7-(2- aminoalkyl)morpholinoquinolones as anti-helicobacter pylori agents
A series of the titled compounds was synthesized and tested for anti- Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore