- Kopsirachin, ein ungewoehnliches Alkaloid aus der Apocynaceae Kopsia dasyrachis Ridl.
-
From the leaves of Kopsia dasyrachis Ridl, a new typ of alkaloid, kopsirachine (1) built up from catechin (2) and skytanthine (3) has been isoled.The structure elucidation is based on spectral and chemical evidence.Oxidative cleavage of its derivative 4 with KMnO4 afforded veratric acid which was identified as its methylester by comparison with an authentic sample.Pyrolysis of 1 yielded δ-skythanthine (3).The stereochemistry of the skythanthine substrituents in 1 could not yet be estabilished.
- Homberger, Katharina,Hesse, Manfred
-
-
Read Online
- Tyrosinase Inhibitor from Black Rice Bran
-
The inhibitor of tyrosinase activity in black rice bran was investigated. The methanol extract from black rice bran was re-extracted with hexane, chloroform, ethyl acetate, or water. The ethyl acetate extract had the most potent inhibition against tyrosinase activity by 80.5% at a concentration of 0. 4 mg/mL. Inhibitory compound in the ethyl acetate fraction was isolated by silica gel column chromatography, and identified as protocatechuic acid methyl ester (compound 1) by GC, GC-MS, IR, and 1H and 13C NMR spectroscopy. Compound 1 inhibited 75.4% of tyrosinase activity at a concentration of 0.50 μmol/mL. ID50 (50% inhibition dose) value of compound 1 was 0.28 μmol/mL. To study the structure-activity relationship, protocatechuic acid (2), vanillic acid (3), vanillic acid methyl ester (4), isovanillic acid (5), isovanillic acid methyl ester (6), veratric acid (7), and veratric acid methyl ester (8) were also assayed.
- Miyazawa, Mitsuo,Oshima, Teruo,Koshio, Katsuya,Itsuzaki, Yumi,Anzai, Jun
-
-
Read Online
- Mechanistic studies of base-catalysed lignin depolymerisation in dimethyl carbonate
-
The depleting fossil reservoirs have stimulated global research initiatives on renewable lignin feedstocks as sustainable alternatives to petroleum-derived aromatics. Base-catalysed depolymerisation (BCD) is regarded as an economical and efficient approach for the valorisation of technical lignins. The major limiting factor encountered during this process is the re-condensation of the formed phenolic products, which results in lower monomer yields. To diminish these side reactions, we selected alkali earth metal catalysts in dimethyl carbonate (DMC) to produce methylated phenol derivatives as the final products. Herein, we demonstrate for the first time a base-promoted depolymerisation process affording low-molecular weight oils in high yields (52-67 wt%) wherein the employed bases are used in truly catalytic quantities (with catalyst loadings of around 5 mol%). The general applicability of this methodology was proved on four different lignin samples (1 Kraft, 3 organosolv) using caesium carbonate and lithium tert-butoxide as catalysts. The 2D NMR studies on the post-reaction lignin samples showed a similar degradation of the major lignin linkages for both bases. A difference in the reduction of phenolic moieties was revealed by quantitative 31P NMR analysis. Furthermore, GPC analysis demonstrated a significant shift towards lower mass fragments for the Cs2CO3-catalysed lignin degradation. A detailed GC-MS analysis for these samples identified a range of methoxy capped-monomeric degradation products. The scope of this reaction system was further expanded to lignocellulosic biomass such as milled beechwood chips, which notably showed similar product distributions. Based on the correlation of the experimental observations for extracted lignin samples and model compound studies, a mechanistic pathway for the Cs2CO3-catalysed system was suggested. DFT calculations provided reaction pathways for the observed cleavage products.
- Dabral, Saumya,Engel, Julien,Mottweiler, Jakob,Spoehrle, Stephanie S. M.,Lahive, Ciaran W.,Bolm, Carsten
-
-
Read Online
- Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids
-
The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.
- Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna
-
supporting information
p. 685 - 689
(2021/04/09)
-
- BCL-2 INHIBITOR
-
Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.
- -
-
Paragraph 0836-0838
(2021/10/22)
-
- Polyhydroxybenzoic acid derivatives as potential new antimalarial agents
-
With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure–activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC50 ~20 μM, SI > 5) often associated with interesting water solubility. Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Methyl 4-benzoxy-3,5-dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosolubility (3.72 mM).
- Degotte, Gilles,Francotte, Pierre,Pirotte, Bernard,Frédérich, Michel
-
-
- Novel arylcarbamate-N-acylhydrazones derivatives as promising BuChE inhibitors: Design, synthesis, molecular modeling and biological evaluation
-
A novel series of arylcarbamate-N-acylhydrazones derivatives have been designed and synthesized as potential anti-cholinesterase agents. In vitro studies revealed that these compounds demonstrated selective for butyrylcholinesterase (BuChE) with potent inhibitory activity. The compounds 10a-d, 12b and 12d were the most potent BuChE inhibitors with IC50 values of 0.07–2.07 μM, highlighting the compound 10c (IC50 = 0.07 μM) which showed inhibitory activity 50 times greater than the reference drug donepezil (IC50 = 3.54 μM). The activity data indicates that the position of the carbamate group in the aromatic ring has a greater influence on the inhibitory activity of the derivatives. The enzyme kinetics studies indicate that the compound 10c has a non-competitive inhibition against BuChE with Ki value of 0.097 mM. Molecular modeling studies corroborated the in vitro inhibitory mode of interaction and show that compound 10c is stabilized into hBuChE by strong hydrogen bond interaction with Tyr128, π-π stacking interaction with Trp82 and CH?O interactions with His438, Gly121 and Glu197. Based on these data, compound 10c was identified as low-cost promising candidate for a drug prototype for AD treatment.
- Yamazaki, Diego A.S.,Rozada, Andrew M.F.,Baréa, Paula,Reis, Elaine C.,Basso, Ernani A.,Sarragiotto, Maria Helena,Seixas, Flávio A.V.,Gauze, Gisele F.
-
-
- Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide
-
An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.
- Bismuto, Alessandro,Boehm, Philip,Morandi, Bill,Roediger, Sven
-
p. 17887 - 17896
(2020/08/19)
-
- Synthesis of Some Aromatic and Aliphatic Esters Using WO3/ZrO2 Solid Acid Catalyst under Solvent Free Conditions
-
A simple method is delineated for the synthesis of substituted ester products in superior yields by esterification reaction under solvent unbound condition using tungsten upgraded ZrO2 solid acid catalyst at 353 K. The WO3/ZrO2 catalyst has been prepared by using impregnation method followed by calcination at 923 K over a period of 6 h in air atmosphere. SEM, XRD, FTIR, and BET surface area techniques were used to categorize this catalyst. Zirconia has both acidic and basic possessions which can be changed by incorporating suitable promoter atom like tungsten which in turn increases the surface area thereby enhancing the surface acidity. Impregnation of W6+ ions exhibits a strong influence on phase modification of zirconia from thermodynamically solid monoclinic to metastable tetragonal phase. Amalgamation of promoter W6+ will stabilize tetragonal phase which is active in catalyzing reactions. In esterification reaction WO3/ZrO2 catalyst was found to be stable, efficient and environmental friendly, effortlessly recovered by filtration, excellent yield of product and can be reusable efficiently.
- Guguloth, Vijaya Charan,Battu, Satyanarayana
-
p. 2153 - 2157
(2020/09/16)
-
- THIOXANTHONE DERIVATIVES, COMPOSITION COMPRISING THE SAME AND PATTERN FORMING METHOD COMPRISING SAID COMPOSITION
-
Latent photoinitiator compounds are described, as well as compositions containing such compounds and their uses in photoinitated methods for producing photoresist structures.
- -
-
Paragraph 0154
(2020/02/14)
-
- OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE
-
Compounds of Formulae I, II, their pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formulae I or II as effective modulators of STING are also provided.
- -
-
Page/Page column 99
(2020/11/30)
-
- Cobalt Nanoparticles-Catalyzed Widely Applicable Successive C?C Bond Cleavage in Alcohols to Access Esters
-
Selective cleavage and functionalization of C?C bonds have important applications in organic synthesis and biomass utilization. However, functionalization of C?C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, we describe an unprecedented efficient protocol for the breaking of successive C?C bonds in alcohols to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcohols including inactive long-chain alkyl aryl alcohols undergo smoothly successive cleavage of adjacent ?(C?C)n? bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C?C bonds to achieve excellent catalytic activity, while the presence of Co-Nx has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.
- Dai, Wen,Gao, Shuang,Li, Guosong,Luo, Huihui,Lv, Ying,Shang, Sensen,Wang, Lianyue
-
supporting information
p. 19268 - 19274
(2020/08/26)
-
- Catalytic Activation of Carbon-Hydrogen Bonds in Lignin Linkages over Strong-Base-Modified Covalent Triazine Frameworks for Lignin Oxidative Cleavage
-
The design of highly efficient catalysts for the cleavage of various lignin linkages is the key step in the depolymerization of lignin. In this paper, strong-base-modified covalent triazine frameworks (CTFs) were reported to be effective in the cleavage o
- Gao, Jin,Liu, Meng,Shi, Song,Xu, Jie,Zhao, Li,Zhu, Guozhi
-
p. 7526 - 7534
(2020/08/21)
-
- Biological Characterization, Mechanistic Investigation and Structure-Activity Relationships of Chemically Stable TLR2 Antagonists
-
Toll-like receptors (TLRs) build the first barrier in the innate immune response and therefore represent promising targets for the modulation of inflammatory processes. Recently, the pyrogallol-containing TLR2 antagonists CU-CPT22 and MMG-11 were reported; however, their 1,2,3-triphenol motif renders them highly susceptible to oxidation and excludes them from use in extended experiments under aerobic conditions. Therefore, we have developed a set of novel TLR2 antagonists (1–9) based on the systematic variation of substructures, linker elements, and the hydrogen-bonding pattern of the pyrogallol precursors by using chemically robust building blocks. The novel series of chemically stable and synthetically accessible TLR2 antagonists (1–9) was pharmacologically characterized, and the potential binding modes of the active compounds were evaluated structurally. Our results provide new insights into structure-activity relationships and allow rationalization of structural binding characteristics. Moreover, they support the hypothesis that this class of TLR ligands bind solely to TLR2 and do not directly interact with TLR1 or TLR6 of the functional heterodimer. The most active compound from this series (6), is chemically stable, nontoxic, TLR2-selective, and shows a similar activity with regard to the pyrogallol starting points, thus indicating the variability of the hydrogen bonding pattern.
- Bermudez, Marcel,Grabowski, Maria,Murgueitio, Manuela S.,Rademann, J?rg,Rudolf, Thomas,Tiemann, Markus,Varga, Péter,Weindl, Günther,Wolber, Gerhard
-
-
- A multicentre synergistic polyoxometalate-based metal-organic framework for one-step selective oxidative cleavage of β-: O -4 lignin model compounds
-
A novel mixed-valence polyoxovanadate-based copper-organic framework, [CuI(bbi)]2{[CuI(bbi)]2VIV2VV8O26}·2H2O (NENU-MV-5, bbi = 1,1′-(1,4-butanediyl)bis(imidazole)), was facilely synthesized from routine reagents under mild hydrothermal conditions. Using NENU-MV-5 as a heterogeneous catalyst without any co-catalyst, one-step oxidative cleavage of β-O-4 lignin into phenols and aromatic acids with high catalytic activity and selectivity was realized under an oxygen atmosphere. No obvious decrease in activity was observed after five cycles, which indicates the excellent stability and sustainability of NENU-MV-5. The perfect catalytic performance of NENU-MV-5 can be attributed to the multi-site synergistic effect of the mixed-valence VV-O-VIV sites on polyoxovanadate for the oxidation of β-O-4 alcohol to β-O-4 ketone and the Cu(i) sites on the framework for the rapid cleavage of the Cα-Cβ bond of β-O-4 ketone. This system represented the first co-catalyst-free example for the one-step selective degradation of lignin catalyzed by a well-defined crystalline catalyst with definite composition and structure in a single solvent.
- Tian, Hong-Rui,Liu, Yi-Wei,Zhang, Zhong,Liu, Shu-Mei,Dang, Tian-Yi,Li, Xiao-Hui,Sun, Xiu-Wei,Lu, Ying,Liu, Shu-Xia
-
p. 248 - 255
(2020/01/13)
-
- Au-Pd alloy cooperates with covalent triazine frameworks for the catalytic oxidative cleavage of β-O-4 linkages
-
To design highly efficient catalysts for the cleavage of the C-O/C-C bond is the key task in the depolymerization of lignin. Bimetallic alloy catalysts Au-Pd-CTFs were developed to be effective in the oxidative cleavage of β-O-4 lignin model compounds with O2. Au-Pd nanoparticles with an Au/Pd molar ratio between 1?:?1 and 1?:?1.5 showed the highest cleavage efficiency. The kinetics of the reaction process revealed that a synergistic effect between Au and Pd played a crucial role in the oxidation of Cα-OH into CαO, which was the rate-determining step for the whole oxidative cleavage process. Further insight revealed that the cooperative effect between Au-Pd nanoparticles and the support covalent triazine frameworks (CTFs) facilitated the cleavage of the formed β-O-4 ketone compound to the corresponding aromatics. In addition, Au-Pd-CTF catalysts also showed efficiency in the oxidative transformation of the organosolv lignin. This catalytic system will provide guidance in the oxidative cleavage of β-O-4 linkages in lignin.
- Zhao, Li,Shi, Song,Zhu, Guozhi,Liu, Meng,Gao, Jin,Xu, Jie
-
supporting information
p. 6707 - 6716
(2019/12/26)
-
- 1,3-Dibromo-5,5-dimethylhydantoin as a Precatalyst for Activation of Carbonyl Functionality
-
Activation of carbonyl moiety is one of the most rudimentary approaches in organic synthesis and is crucial for a plethora of industrial-scale condensation reactions. In esterification and aldol condensation, which represent two of the most important reactions, the susceptibility of the carbonyl group to nucleophile attack allows the construction of a variety of useful organic compounds. In this context, there is a constant need for development of and improvement in the methods for addition-elimination reactions via activation of carbonyl functionality. In this paper, an advanced methodology for the direct esterification of carboxylic acids and alcohols, and for aldol condensation of aldehydes using widely available, inexpensive, and metal-free 1,3-dibromo-5,5-dimethylhydantoin under neat reaction conditions is reported. The method is air- and moisture-tolerant, allowing simple synthetic and isolation procedures for both reactions presented in this paper. The reaction pathway for esterification is proposed and a scale-up of certain industrially important derivatives is performed.
- ?ebular, Klara,Bo?i?, Bojan ?.,Stavber, Stojan
-
supporting information
(2019/08/01)
-
- Nitrogen Dioxide Catalyzed Aerobic Oxidative Cleavage of C(OH)–C Bonds of Secondary Alcohols to Produce Acids
-
Stable organic nitroxyl radicals are an important class of catalysts for oxidation reactions, but their wide applications are hindered by their steric hinderance, high cost, complex operation, and separation procedures. Herein, NO2 in DMSO is shown to effectively catalyze the aerobic oxidative cleavage of C(OH)?C bonds to form a carboxylic group, and NO2 was generated in situ by decomposition of nitrates. A diverse range of secondary alcohols were selectively converted into acids in excellent yields in this transition-metal-free system without any additives. Preliminary results also indicate its applicability to depolymerize recalcitrant macromolecular lignin. Detail studies revealed that NO2 from nitrates promoted the reaction, and NO2 served as hydrogen acceptor and radical initiator for the tandem oxidative reaction.
- Liu, Mingyang,Zhang, Zhanrong,Song, Jinliang,Liu, Shuaishuai,Liu, Huizhen,Han, Buxing
-
p. 17393 - 17398
(2019/11/11)
-
- A room temperature next amine control lignin model molecular breaking method
-
The invention relates to a room temperature next amine control lignin model molecular breaking method. The method adopts the 1 - aryl - 2 - [...] as lignin β - O - 4 model molecule, in under the action of the copper salt and an amine, is oxidized and broken C - C/C - O key; wherein a primary and secondary aliphatic amine control into aromatic amide and a phenolic compound, inorganic ammonia control generating α - one amide and phenolic compound, tertiary amine control into aromatic acid and phenol compounds. The testing process are as follows: the 1 - aryl - 2 - [...], amine compound with a copper salt in dimethyl sulfoxide in mixed, put in the pressure container, the charge air or oxygen after the replacement is closed, at room temperature, stirring the reaction 8 - 12 is H, can occur model molecular C - C/C - O bond breaking, to obtain aromatic amide, α - one amide, aromatic acid and phenol compounds. The mild conditions, cheap catalyst and oxidizing agent, various controllable reaction product, the reaction process is simple and easy to operate.
- -
-
Paragraph 0058; 0059; 0060; 0061; 0062; 0063; 0075; 0076
(2019/06/30)
-
- Cobalt Nanoparticles Embedded in N-Doped Porous Carbon Derived from Bimetallic Zeolitic Imidazolate Frameworks for One-Pot Selective Oxidative Depolymerization of Lignin
-
Cobalt nanoparticles embedded in N-doped porous carbon (Co@CN) were prepared by the pyrolysis of bimetallic zeolitic imidazolate frameworks (BMZIFs) based on ZIF-8 and ZIF-67. The catalyst shows excellent catalytic efficiency in one-pot selective oxidative cleavage of different linkages like β-O-4, a-O-4 and β-1 in organosolv lignin and lignin model compounds in the presence of oxygen (ambient pressure) under mild conditions (383 K). Compared with traditional supported catalyst, the catalyst gives a highly hollow structure, which favored the adsorption of substrates and oxygen. The uniform cobalt nanoparticles surrounded by N-doped graphitic structures and the strong electron transfer from graphitic nitrogen to Co NPs make it hard to be oxidized prior to use and higher catalytic reactivity. Moreover, the catalyst can be easily recovered by magnetic force after the reaction, and reused after reduction for five times without an obvious change in yields.
- Sun, Kangkang,Chen, Shujie,Zhang, Jiawei,Lu, Guo-Ping,Cai, Chun
-
p. 1264 - 1271
(2019/02/01)
-
- Method for preparing carboxylic ester by alcohol direct oxidation esterification method
-
The invention discloses a method for preparing a carboxylic ester by an alcohol direct oxidation esterification method. The method comprises the following steps: taking an aromatic alcohol compound ora saturated linear aliphatic alcohol as a reaction substrate, taking an Au-Co composite particle carrier as a catalyst, adding a low catalytic amount of alkali, reacting for 0.5-15 h in a methanol solvent at the temperature of 25-150 DEG C in air or oxygen or a mixed atmosphere of the air or the oxygen, and performing aftertreatment to obtain a target product carboxylic ester. According to the preparation method disclosed by the invention, the process steps are reduced, conditions are mild, catalyst consumption is less, atom economy is high, the method is simple to operate, the application range of the substrate is wide, and industrial practicability is achieved.
- -
-
Paragraph 0056; 0057
(2019/06/30)
-
- Dehydrogenative cross-coupling of primary alcohols to form cross-esters catalyzed by a manganese pincer complex
-
Base-metal-catalyzed dehydrogenative cross-coupling of primary alcohols to form cross-esters as major products, liberating hydrogen gas, is reported. The reaction is catalyzed by a pincer complex of earth-abundant manganese in the presence of catalytic base, without any hydrogen acceptor or oxidant. Mechanistic insight indicates that a dearomatized complex is the actual catalyst, and indeed this independently prepared dearomatized complex catalyzes the reaction under neutral conditions.
- Das, Uttam Kumar,Ben-David, Yehoshoa,Leitus, Gregory,Diskin-Posner, Yael,Milstein, David
-
p. 479 - 484
(2019/01/11)
-
- Woody species: A new bio-based material for dual Ca/Mg catalysis with remarkable Lewis acidity properties
-
Advances in green catalysis have promoted the development of ecocatalysis encountered in most of the main transformations of organic chemistry. Taking advantage of the remarkable capacity of certain plants to hyperaccumulate transition metals into shoots or roots, we have addressed the direct use of metals derived from contaminated plant wastes as supported Lewis acid catalysts, coupling agents, oxidative and reducing catalysts in green chemistry. This approach constituted the first example of chemical catalyst based on phytotechnologies. Herein, we show that the concept can be extended to common and abundant plant species that are surprisingly appropriated for chemical catalysis. We present that willow, birch, plane and linden trees can be used to produce bio-based and original Lewis acid catalysts. The catalytic potential of these species will be illustrated through two representative transformations, acetalisation and oxidative esterification. Thanks to their original polymetallic composition, ecocatalysts provided better results compared to classical metal chlorides such as MgCl2, CaCl2 or ZnCl2. This illustrates the interest of the ecocatalysis and is incorporated within the green and sustainable chemistry concept.
- Deyris, Pierre-Alexandre,Adler, Pauline,Petit, Eddy,Legrand, Yves-Marie,Grison, Claude
-
p. 3133 - 3142
(2019/06/18)
-
- A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids
-
Herein, we present a study on the oxidation of aldehydes to carboxylic acids using three recombinant aldehyde dehydrogenases (ALDHs). The ALDHs were used in purified form with a nicotinamide oxidase (NOx), which recycles the catalytic NAD+ at the expense of dioxygen (air at atmospheric pressure). The reaction was studied also with lyophilised whole cell as well as resting cell biocatalysts for more convenient practical application. The optimised biocatalytic oxidation runs in phosphate buffer at pH 8.5 and at 40 °C. From a set of sixty-one aliphatic, aryl-Aliphatic, benzylic, hetero-Aromatic and bicyclic aldehydes, fifty were converted with elevated yield (up to >99%). The exceptions were a few ortho-substituted benzaldehydes, bicyclic heteroaromatic aldehydes and 2-phenylpropanal. In all cases, the expected carboxylic acid was shown to be the only product (>99% chemoselectivity). Other oxidisable functionalities within the same molecule (e.g. hydroxyl, alkene, and heteroaromatic nitrogen or sulphur atoms) remained untouched. The reaction was scaled for the oxidation of 5-(hydroxymethyl)furfural (2 g), a bio-based starting material, to afford 5-(hydroxymethyl)furoic acid in 61% isolated yield. The new biocatalytic method avoids the use of toxic or unsafe oxidants, strong acids or bases, or undesired solvents. It shows applicability across a wide range of substrates, and retains perfect chemoselectivity. Alternative oxidisable groups were not converted, and other classical side-reactions (e.g. halogenation of unsaturated functionalities, Dakin-Type oxidation) did not occur. In comparison to other established enzymatic methods such as the use of oxidases (where the concomitant oxidation of alcohols and aldehydes is common), ALDHs offer greatly improved selectivity.
- Knaus, Tanja,Tseliou, Vasilis,Humphreys, Luke D.,Scrutton, Nigel S.,Mutti, Francesco G.
-
p. 3931 - 3943
(2018/09/11)
-
- Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis
-
Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.
- Ganesh Kumar,Gautham Shenoy,Kar, Sidhartha Sankar,Shenoy, Vishnu,Bairy, Indira
-
p. 907 - 917
(2018/02/07)
-
- Method for catalyzing oxidative cracking of lignin by heterogeneous cobalt
-
The invention discloses a method for catalyzing oxidative cracking of lignin by a heterogeneous cobalt. The method adopts a porous carbon-nitrogen-loaded cobalt nano-material as a catalyst, and oxidative cracking of beta-O-4, alpha-O-4 and beta-1 lignin template compounds and solvent type lignin is carried out under the action of the catalyst with methanol as a solvent and oxygen as an oxidant inorder to obtain phenol, methyl benzoate and other small molecule compounds. The heterogeneous cobalt catalyst adopted in the invention realizes a wide application range of a substrate, is suitable forthe oxidative cracking of the beta-O-4, alpha-O-4 and beta-1 lignin template compounds and solvent type lignin, realizes high yield of a product and no polymerization of the product, and can be simply recovered through magnetic force after the reaction ends.
- -
-
Paragraph 0024; 0025; 0026
(2018/11/26)
-
- Protection of COOH and OH groups in acid, base and salt free reactions
-
We report an iron-catalyzed general functional group protection method with inexpensive reagents. This environmentally benign process does not use acids or bases, and does not produce waste products. Further purification beyond filtration and evaporation is, in most cases, unnecessary. Free COOH and OH groups can be protected in a one-pot reaction.
- Zhu, Xiaotao,Qian, Bo,Wei, Rongbiao,Huang, Jian-Dong,Bao, Hongli
-
supporting information
p. 1444 - 1447
(2018/04/12)
-
- Formation of esters and amides via metal-free Csp2-Csp3 bond cleavage of α-nitro ketone: Mechanistic insight to the reaction pathway
-
A catalyst free protocol for hucleophilic Csp2-Csp3 bond cleavage of a-nitroketone has been achieved for the formation of C-O and C-N bond. A series of differently substituted a-nitroketones could be selectively cleaved and converted into corresponding esters and tosylamides in presence of alcohols and bromamine-T respectively. Mechanism of the C-C bond cleavage has been proposed by identifying different reaction intermediates using IR and NMR spectroscopic methods.
- Sarma, Manas Jyoti,Phukan, Prodeep
-
p. 523 - 533
(2019/05/21)
-
- Composition FOR PREVENTING ALOPECIA AND ACTIVATING HAIR GROWTH
-
The present invention provides a hair growth promoter comprising as an active ingredient, a compound having a chemical structure of general formula (1) or a pharmacologically acceptable salt thereof. In the general formula (1): R_1 is a saturated or unsaturated straight chain or branched C1-C10 alkyl group or hydroxy alkyl group; R_2 is hydrogen or a saturated or unsaturated straight chain or branched C1-C10 alkoxy or hydroxy alkoxy; X is hydrogen, hydroxy, or a saturated or unsaturated straight chain or branched C1-C10 alkyl group, alkoxy or hydroxyl alkoxy; R_3 and R_4 are each independently selected from R_5, hydrogen, aldehyde, and a saturated or unsaturated straight chain or branched alkyl, alkoxy, or hydroxy alkoxy; R_5 has a structure of # AAA #; R_6 is selected from hydrogen, and a saturated or unsaturated straight chain or branched C1-C10 alkyl, alkoxy, or hydroxy alkoxy; and one of R_3 and R_4 is hydrogen.COPYRIGHT KIPO 2017
- -
-
Paragraph 0204; 0215; 0216
(2018/02/16)
-
- Dioxolone structure containing 4 - N substituted quinazoline derivatives and its preparation and use (by machine translation)
-
The invention discloses a dioxolone structure containing 4 -NSubstituted quinazoline derivatives, its structure such as shown in I. This invention has introduced to substituted benzoic acid, methanol, nitric acid, formamide, trichloro oxygen phosphorus chlorine, nitrobenzene formaldehyde, acetone, stannous chloride, substituted aromatic aldehyde as raw material, by the multi-step reaction to synthesize the target compound. The compounds can be used as anti-tumor, anti-bacterial plant and anti-plant-virus of the drug. (1 E, 4 E) - 1 - substituted phenyl - 5 - (4 - (substituted quinazoline - 4 - amino) phenyl) - 1, 4 - pentadiene - 3 - one. (by machine translation)
- -
-
Paragraph 0043; 0044
(2017/11/16)
-
- Acid promoted C-C bond oxidative cleavage of β-O-4 and β-1 lignin models to esters over a copper catalyst
-
Depolymerisation of lignin to aromatics is a challenging task. We herein report that a Cu(OAc)2/BF3·OEt2 catalyst is effective in simultaneously cleaving C-C bonds in β-1 and β-O-4 ketones, yielding esters and phenols. In-depth studies show that C-H bond activation is the rate determining step for C-C bond cleavage. BF3·OEt2 promotes the reaction via activating the β-C-H bond. This study offers the potential to obtain aromatic esters from lignin.
- Wang,Li,Lu,Li,Zhang,Liu,Luo,Wang
-
p. 702 - 706
(2017/08/15)
-
- Highly effective C-C bond cleavage of lignin model compounds
-
A highly effective method is developed for the C-C bond cleavage of lignin model compounds. The inert Cα-Cβ or Cα-Cphenyl bond of oxidized lignin model compounds was successfully converted to an active ester bond through the classic organic name reaction, Baeyer-Villiger (BV) oxidation, and thus acetal esters and aryl esters were produced in high yields (up to 99%) at room temperature. Next, K2CO3 catalyzed the alcoholysis of the resulting ester products at 45 °C, affording various useful chemical platforms in excellent yields (up to 99%), such as phenols and multifunctional esters. This method uses commercially available reagents, is transition-metal free and simple, but highly effective, and involves mild reaction conditions.
- Wang, Yinling,Wang, Qianyi,He, Jianghua,Zhang, Yuetao
-
supporting information
p. 3135 - 3141
(2017/07/24)
-
- Investigate cleavage of β-O-4 linkage in lignin model compounds by aerobic oxidation of Cα and Cγ hydroxyl groups
-
The selective cleavage of common linkages in lignin polymers is a promising approach to generate valuable aromatic hydrocarbons. Herein, we found that on oxidation of Cα and Cγ hydroxyl groups in β-O-4 lignin model compounds with TEMPO catalyst resulted in the formation of 1,3-dicarbonyl TEMPO adduct. These oxidized products readily underwent fragmentation at Cα-Cβ bond in the presence of a catalytic amount of acid to generate corresponding carboxylic acid and phenol monomers.
- Patil, Nikhil D.,Yan, Ning
-
p. 3024 - 3028
(2016/07/06)
-
- NOVEL SINGLE STEP ESTERIFICATION PROCESS OF ALDEHYDES USING A HETEROGENEOUS CATALYST
-
The present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using a heterogeneous catalyst with high yields. More particularly, the present invention relates to a novel simple, efficient and single-step process for esterification of aldehydes using Titanium superoxide with greater than 80% yields.
- -
-
Page/Page column 7; 9
(2016/06/20)
-
- Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities
-
A novel group of 1,3,4-oxadaiazoles, a group known for their anti-inflammatory activity, is hybridized with nitric oxide (NO) releasing group, oxime, for its gastro-protective action and potential synergistic effect. The synthesized hybrids were evaluated for their anti-inflammatory, analgesic, antioxidant and ulcerogenic activities. Most of the tested compounds showed excellent anti-inflammatory activity with compound 8e being more active than indomethacin. They also showed moderate analgesic activity but no antioxidant one. The ability of the synthesized compounds to inhibit COX-1 and COX-2 is studied and the prepared compounds were able to inhibit both COXs non-selectively with IC50s of 0.75–70.50?μM. Docking studies revealed the mode of interaction of the tested compounds into the empty pocket of the isozymes. All of the synthesized compounds interact with COXs active site with energy scores comparable to that of ibuprofen. All compounds showed a safer profile on the stomach tissue integrity compared to conventional NSAIDs. The designed strategy was applied to ibuprofen to introduce ibuprofen/oxadiazole/NO hybrid. The synthesized ibuprofen hybrid is a promising alternative to ibuprofen having similar anti-inflammatory activity but with safer GIT profile.
- Abd-Ellah, Heba S.,Abdel-Aziz, Mohamed,Shoman, Mai E.,Beshr, Eman A.M.,Kaoud, Tamer S.,Ahmed, Al-Shaimaa F.F.
-
supporting information
p. 48 - 63
(2016/09/28)
-
- An efficient nonconventional glycerol-based solid acid catalyzed synthesis and biological evaluation of phosphonate conjugates of 1,2,4-triazole thiones
-
A series of diethyl (3-((5-aryl-1H-1,2,4-triazol-3-yl)thio)propyl)phos-phonates (7a-t) has been synthesized in excellent yields by coupling diethyl (3-bromopropyl)phosphonate and 5-aryl-1H- 1,2,4-triazol-3-thiones employing an efficient, green and nonconventional heterogeneous SO3Hcarbon catalyst derived from glycerol. In addition, a facile and green approach for the esterification of carboxylic acids by utilizing glycerol-based solid acid catalyst has been reported. Structures of the synthesized compounds were characterized by IR, NMR and HRMS studies. These triazole derivatives were screened for their in vitro cytotoxicity using the standard MTT (3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetra-zolium bromide) assay against a panel of five different human cancer cell lines (HeLa: Cervix, A549: Lung, A375: Skin, MDA-MB-231: Breast and T98G: Brain). The antimicrobial activities of the synthesized compounds were investigated against four bacterial strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and three fungal strains: Aspergillus Niger, Aspergillus terreus, Aspergillus fumigatus. Preliminary results indicate that the compound 7f displayed maximum anticancer activity and the compounds 7d, 7e, 7f, 7m and 7q exhibited moderate antibacterial activity. The compounds 7g, 7h, 7o and 7p showed good antifungal activity with high inhibition zone diameter compared to the standard drug.
- Murty, Madugula S.R.,Katiki, Mohana R.,Rao, Busam R.,Narayanan, Sai S.,Anto, Ruby J.,Buddana, Sudhreer K.,Prakasham, Reddy S.,Devi, Bethala L.A.P.,Prasad, Rachapudi B.N.
-
p. 968 - 981
(2016/10/31)
-
- Chemoselective dehydrogenative esterification of aldehydes and alcohols with a dimeric rhodium(II) catalyst
-
Dehydrogenative cross-coupling of aldehydes with alcohols as well as dehydrogentive cross-coupling of primary alcohols to produce esters have been developed using a Rh-terpyridine catalyst. The catalyst demonstrates broad substrate scope and good functional group tolerance, affording esters highly selectively. The high chemoselectivity of the catalyst stems from its preference for dehydrogenation of benzylic alcohols over aliphatic ones. Preliminary mechanistic studies suggest that the active catalyst is a dimeric Rh(ii) species, operating via a mechanism involving metal-base-metal cooperativity.
- Cheng, Junjie,Zhu, Meijuan,Wang, Chao,Li, Junjun,Jiang, Xue,Wei, Yawen,Tang, Weijun,Xue, Dong,Xiao, Jianliang
-
p. 4428 - 4434
(2016/07/07)
-
- Ultrasound-Assisted Methyl Esterification of Carboxylic Acids ACatalyzed by Polymer-Supported Triphenylphosphine
-
A convenient and efficient sonochemical method for methyl esterification of carboxylic acids catalyzed by polymer-supported triAphenylphosphine (PS-Ph3P) is reported. In the presence of 1:0.1:2 molar ratio of 2,4,6-trichloro-1,3,5-triazine/PS-Ph3P/Na2CO3, methyl esters of various carboxylic acids bearing reactive hydroxyl groups as well as acid-or base-labile functionalities could be rapidly prepared (within 10-20 min) in good to excellent yields without necessity to pre-activate the acids. Using the polymer-bound phosphine also allows easy isolation of the products which, in most of the cases, were obtained in high purities without column chromatography.
- Jaita, Subin,Phakhodee, Wong,Pattarawarapan, Mookda
-
p. 2006 - 2008
(2015/09/01)
-
- HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
-
Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).
- -
-
Paragraph 00288
(2015/11/10)
-
- Base-catalysed cleavage of lignin β-O-4 model compounds in dimethyl carbonate
-
A base-catalysed transformation and cleavage of lignin β-O-4 model compounds in dimethyl carbonate is reported. The reaction system consists of readily available bases and inexpensive dimethyl carbonate as a solvent and reagent, affording methoxy benzene or 2-aryloxyvinyl benzene derivatives in good to very good yields. The applicability of the system for the bond cleavage in an organosolv lignin sample was demonstrated.
- Dabral, Saumya,Mottweiler, Jakob,Rinesch, Torsten,Bolm, CarstenU
-
supporting information
p. 4908 - 4912
(2015/11/11)
-
- Formation of new C-O and C-N bonds via base promoted Csp2-Csp3 bond cleavage of α-nitro ketone
-
A catalyst free protocol has been developed for nucleophilic Csp2-Csp3 bond cleavage of α-nitroketone in the presence of potassium carbonate to create new C-O and C-N bonds. A series of different substituted α-nitroketones could be selectively cleaved and converted into corresponding esters and tosylamides in the presence of alcohols and bromamine-T, respectively.
- Sarma, Manas Jyoti,Borah, Arun Jyoti,Rajbongshi, Kamal Krishna,Phukan, Prodeep
-
supporting information
p. 7008 - 7011
(2015/11/27)
-
- Copper-mediated oxidative homocoupling and rearrangement of N-alkoxyamides: An efficient method for the preparation of aromatic esters
-
N-Alkoxyamides are successfully converted into their corresponding esters in a moderate to satisfactory yields via copper-catalyzed oxidative homocoupling and Heron rearrangement. The process tolerates a wide variety of functional groups and allows the synthesis of sterically hindered ester products not readily accessible by traditional acylation chemistry. A radical-mediated pathway has been tentatively proposed for the oxidative process.
- Duan, Xiyan,Yang, Kun,Tian, Shuang,Ma, Junying,Li, Yaning,Zou, Jiao,Zhang, Dongliang,Cui, Huanqing
-
supporting information
p. 4634 - 4637
(2015/07/08)
-
- Direct oxidative esterification of alcohols and hydration of nitriles catalyzed by a reusable silver nanoparticle grafted onto mesoporous polymelamine formaldehyde (AgNPs@mPMF)
-
A nitrogen-rich mesoporous organic polymer was synthesized as a novel support. A silver nanoparticle was synthesized and grafted onto it. The prepared catalyst (AgNPs@mPMF) was characterized by powder X-ray diffraction (XRD), scanning electron microscopy(SEM) and energy dispersive X-ray spectrometry (EDS), thermogravimetric analysis (TGA), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflectance spectroscopy (DRS), N2 adsorption, Raman spectroscopy and EPR study. The catalytic activity was evaluated for the oxidative esterification reaction of alcohols and hydration of nitriles. The oxidative esterification reaction was carried out for various activated alcohols giving excellent yields of the corresponding ester products. The catalyst was also efficient in the hydration of nitriles. Both reactions were optimized by varying the bases, temperatures and solvents. The catalyst can be facilely recovered and reused six times without a significant decrease in its activity and selectivity.
- Ghosh, Kajari,Iqubal, Md. Asif,Molla, Rostam Ali,Mishra, Ashutosh,Kamaluddin,Islam, Sk Manirul
-
p. 1606 - 1622
(2015/04/27)
-
- Titanium superoxide-a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant
-
Titanium superoxide efficiently catalysed the oxidative esterification of aldehydes with alkylarenes or alcohols, under truly heterogeneous conditions, to afford the corresponding benzyl and alkyl esters in excellent yields. Mechanistic studies have established that this "one pot" direct oxidative esterification process proceeds through a radical pathway, proven by a FTIR spectral study of a titanium superoxide-aldehyde complex as well as spin trapping experiments with TEMPO. The intramolecular version of this protocol has been successfully demonstrated in the concise synthesis of 3-butylphthalide, an anti-convulsant drug.
- Dey, Soumen,Gadakh, Sunita K.,Sudalai
-
p. 10631 - 10640
(2015/11/17)
-
- Highly efficient dehydrogenative cross-coupling of aldehydes with amines and alcohols
-
A common protocol for the synthesis of amides, esters and α-ketoesters via cross dehydrogenative coupling of aldehydes and amines/alcohols has been developed. The method is applicable to a wide variety of alcohols and amines as well as aliphatic and aromatic aldehydes. Also, the use of acetaldehyde for acetylation and ethyl glyoxalate to access 2-oxo-amino esters is presented for the first time.
- Deshidi, Ramesh,Rizvi, Masood Ahmad,Shah, Bhahwal Ali
-
p. 90521 - 90524
(2015/11/11)
-
- Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives
-
A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.
- Murty,Ram, Kesur R.,Rao, B. Ramalingeswara,Rao, Rayudu Venkateswara,Katiki, Mohana Rao,Rao, Janapala Venkateswara,Pamanji,Velatooru
-
p. 1661 - 1671
(2014/05/06)
-
- Synthesis and bioactivity of resveratrol analogues
-
It has been reported that resveratrol enhanced SIRT1 expression and significantly mimicked calorie restriction by stimulating Sir2 which is the most homologic homologue of SIRT1 of mammalian. A series of novel resveratrol derivatives were designed and synthesized as novel SIRT1 activator candidates. These synthesized compounds were characterized by spectral (1H NMR) analysis and examined for their Sir2 activation against yeast parental strain-BY4743 at a concentration of 100 μM/L by Bioscreen C MBR machine. Several compounds showed a promising Sir2 activation activity compared with resveratrol. Meanwhile, the structure-activity relationships with Sirt2 activation activities were also discussed.
- Ao, Junli,Chen, Yuanmou,Xu, Xiaoling,Zhang, Xu,Yu, Yue,Yu, Peng,Hua, Erbing
-
p. 2092 - 2098
(2014/06/09)
-
- Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H5N1
-
To find novel compounds against H5N1, three series of known or novel small molecular polyphenols were synthesized and tested in vitro for anti-H5N1 activity. In addition, the preliminary structure-antiviral activity relationships were elaborated. The results showed that some small molecular polyphenols had better anti-H5N1 activity, and could serve as novel virus entry inhibitors against H 5N1, likely targeting to HA2 protein. Noticeably, compound 4a showed the strongest activity against H5N1 among these compounds, and the molecular modeling analysis also suggested that this compound might target to HA2 protein. Therefore, compound 4a is well qualified to serve as a lead compound or scaffold for the further development of H 5N1 entry inhibitor.
- Yang, Jian,Yang, Jing Xiang,Zhang, Fang,Chen, Gang,Pan, Wei,Yu, Rui,Wu, Shuwen,Tien, Po
-
p. 2680 - 2684
(2014/06/09)
-
- NMR methodology for complex mixture 'separation'
-
Mixture 'separation' by NMR is demonstrated through the development of a pseudo 4D NMR experiment, 3D IPAP INEPT-INADEQUATE-HSQC, designed for the structural elucidation of 13C tagged compounds.
- Bell, Nicholle G. A.,Murray, Lorna,Graham, Margaret C.,Uhrin, Dusan
-
supporting information
p. 1694 - 1697
(2014/02/14)
-
- Facile and efficient gold-catalyzed aerobic oxidative esterification of activated alcohols
-
A facile and efficient methodology is presented for the direct oxidative esterification of alcohols with alcohols catalyzed by NaAuCl4. Just in the presence of a low catalytic amount of base additive, the newly developed catalytic system proceeds with high selectivity and broad substrate scope under mild conditions with dioxygen or air as the environmentally benign terminal oxidant. Various alcohols including benzylic and allylic alcohols were smoothly reacted with methanol and even with long-chain aliphatic alcohols, affording the desired products in good to excellent yields (up to 95% yield). The present system showed high catalytic activity with a TOF up to 219 h-1. Kinetic studies of the reaction process provide fundamental insights into the catalytic pathway, and a possible reaction pathway was proposed based on the results of the control experiments. XPS, TEM, and UV-vis were carried out to characterize the chemical state of the Au catalyst in the present catalytic system. The results indicate that the Au nanoparticles were generated in situ and supported on K2CO3, forming a simple, recyclable and selective catalyst system for the direct oxidative esterification of alcohols. the Partner Organisations 2014.
- Wang, Lianyue,Li, Jun,Dai, Wen,Lv, Ying,Zhang, Yi,Gao, Shuang
-
p. 2164 - 2173
(2014/04/17)
-
- A catalyst-free protocol for direct oxidative esterification of alcohols and aldehydes
-
A fast, simple, and efficient protocol for the direct conversion of alcohols and aldehydes to methyl ester has been developed using TsNBr2without any catalyst. The one pot reaction proceeds in the presence of a base at room temperature in methanol, to produce the corresponding methyl ester in high yield within a short time.
- Rajbongshi, Kamal Krishna,Sarma, Manas Jyoti,Phukan, Prodeep
-
p. 5358 - 5360
(2015/01/08)
-
- Copper-catalyzed methyl esterification reactions via C-C bond cleavage
-
The highly effective synthesis of methyl esters from benzylic alcohols, aldehydes, or acids via copper-catalyzed C-C cleavage from tert-butyl hydroperoxide is reported in this paper for the first time. Our protocol is easily accessible and practical, making it a possible supplement for the traditional way.
- Zhu, Yan,Yan, Hong,Lu, Linhua,Liu, Defu,Rong, Guangwei,Mao, Jincheng
-
p. 9898 - 9905
(2013/10/22)
-