- ENZYME INHIBITORS
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The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, and, n, are as defined herein.
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Page/Page column 104; 126; 127
(2021/02/26)
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- ENZYME INHIBITORS
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The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.
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Page/Page column 136-137
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- ENZYME INHIBITORS
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The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, Y, n, R1, R2A, R2B, R3 and *1 are as defined herein.
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Page/Page column 159-160
(2021/02/26)
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- Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors
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Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.
- Rewinkel,Lucas,Smit,Noach,Van Dinther,Rood,Jenneboer,Van Boeckel
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p. 2837 - 2842
(2007/10/03)
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