- Stable liquid foams from a new polyfluorinated surfactant
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Liquid foams exhibiting long-term stability are a key-challenge in material design. Based on this perspective, new pyridinium polyfluorinated surfactants were synthesized from simple building blocks enabling unusually stable liquid foams. While the batch-generated foams were used for qualitative foaming evaluation, microfluidics allowed a quantitative insight into the aging effects of monodisperse foams.
- Russo, Maria,Amara, Zacharias,Fenneteau, Johan,Chaumont-Olive, Pauline,Maimouni, Ilham,Tabeling, Patrick,Cossy, Janine
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supporting information
p. 5807 - 5810
(2020/06/03)
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- Preparation method for synthesizing high-carbon alkyl acrylate through catalyzing in-situ acid resin
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The invention belongs to the technical field of organic synthesis and in particular relates to a preparation method for synthesizing high-carbon alkyl acrylate through catalyzing in-situ acid resin. The preparation method comprises the following steps: mixing acrylic acid, the in-situ acid resin, acrylic high-carbon alkyl alcohol, hydroquinone and cyclohexane according to a certain ratio; stirringand heating, and controlling reaction time; after reaction is finished, filtering to remove a resin catalyst; carrying out water washing, neutralization and water washing to obtain the high-carbon alkyl acrylate. According the preparation method provided by the invention, the yield of high-carbon alkyl acrylate can be improved; the in-situ acid resin can be repeatedly utilized, resources are saved and the environment is protected.
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Paragraph 0041; 0042; 0050-0057
(2018/11/27)
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- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
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CRISPR/Cas is a revolutionary gene editing technology with wide-ranging utility. The safe, non-viral delivery of CRISPR/Cas components would greatly improve future therapeutic utility. We report the synthesis and development of zwitterionic amino lipids (ZALs) that are uniquely able to (co)deliver long RNAs including Cas9 mRNA and sgRNAs. ZAL nanoparticle (ZNP) delivery of low sgRNA doses (15 nm) reduces protein expression by >90 % in cells. In contrast to transient therapies (such as RNAi), we show that ZNP delivery of sgRNA enables permanent DNA editing with an indefinitely sustained 95 % decrease in protein expression. ZNP delivery of mRNA results in high protein expression at low doses in vitro (?1). Intravenous co-delivery of Cas9 mRNA and sgLoxP induced expression of floxed tdTomato in the liver, kidneys, and lungs of engineered mice. ZNPs provide a chemical guide for rational design of long RNA carriers, and represent a promising step towards improving the safety and utility of gene editing.
- Miller, Jason B.,Zhang, Shuyuan,Kos, Petra,Xiong, Hu,Zhou, Kejin,Perelman, Sofya S.,Zhu, Hao,Siegwart, Daniel J.
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supporting information
p. 1059 - 1063
(2017/01/18)
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- Synthesis and Surface Properties of a Novel Sodium 3-(3-Alkyloxy-3-oxopropoxy)-3-oxopropane-1-sulfonate at the Air-Water Interface
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The present paper describes the synthesis and evaluation of surface properties of a novel series of anionic surfactant, namely sodium 3-(3-alkyloxy-3-oxopropoxy)-3-oxopropane-1-sulfonate with varying alkyl chain length (C8-C16). Synthesis involves initial formation of the 3-alkyloxy-3-oxopropyl acrylate along with fatty acrylate during the direct esterification of fatty alcohol with acrylic acid in the presence of 0.5 % NaHSO4 at 110 C followed by sulfonation of the terminal double bond of the 3-alkyloxy-3-oxopropyl acrylate. Synthesized compounds were evaluated for surface and thermodynamic properties such as critical micelle concentration (CMC), surface tension at CMC (γcmc), efficiency of surface adsorption (pC20), surface excess (Γmax), minimum area per molecule at the air-water interface (A min), free energy of adsorption (?G ads), free energy of micellization (?G mic), wetting time, emulsifying properties, foaming power and calcium tolerance. Effect of chain length on CMC follows the classic trend, i.e. decrease in CMC with the increase in alkyl chain length. High pC20 (>3) value indicates higher hydrophobic character of the surfactant. These surfactants showed very poor wetting time and calcium tolerance, but exhibited good emulsion stability and excellent foamability. Foaming power and foam stability of C14-sulfonate were found to be the best among the studied compounds. Foam stability of C14-sulfonate was also studied at different concentrations over time and excellent foam stability was obtained at a concentration of 0.075 %. Thus this novel class of surfactant may find applications as foam boosters in combination with other suitable surfactants.
- Kumar, Pandari Phani,Nayak, Rati Ranjan,Kanjilal, Sanjit
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p. 689 - 695
(2015/06/23)
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- Cosmetic emulsions containing acrylamide copolymer
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Water-in-oil emulsions wherein the emulsifier is a copolymer of 1 mol of acrylamide with 2 to 20 mols of at least one ethylenically unsaturated ester copolymerizable therewith selected from the group consisting of vinyl alkylcarboxylates, alkyl and cycloalkyl acrylates, and alkly and cycloalkyl methacrylates, wherein the alkyl and cycloalkyl groups contain 6 to 24 carbon atoms, and the continuous phase is a cosmetically acceptable oil, which can be prepared easily, safely and inexpensively. The emulsions are substantially odorless and are cosmetically acceptable for the care of the skin.
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