Mechanism-Based Isocoumarin Inhibitors for Human Leukocyte Elastase. Effect of the 7-Amino Substituent and 3-Alkoxy Group in 3-Alkoxy-7-amino-4-chloroisocoumarins on Inhibitory Potency
A series of 3-alkoxy-7-amino-4-chloroisocoumarins with various 3-alkoxy substituents have been prepared and evaluated as inhibitors of human leukocyte elastase (HLE).In addition, a new series of acyl, urea, and carbamate derivatives of 7-amino-4-chloro-3-
Kerrigan, John E.,Oleksyszyn, Jozef,Kam, Chih-Min,Selzler, Joe,Powers, James C.
p. 544 - 552
(2007/10/02)
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