- IMIDAZOPYRIDINES SYK INHIBITORS
-
Certain imidazopyridines (I) and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
- -
-
Paragraph 0372
(2014/06/11)
-
- IMIDAZOPYRIDINES SYK INHIBITORS
-
Certain imidazopyridines (I) and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
- -
-
Page/Page column 69
(2011/10/05)
-
- ANTI-VIRAL COMPOUNDS
-
Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
- -
-
Page/Page column 58
(2008/12/08)
-
- Protection of Primary Amines as N-Substituted 2,5-Dimethylpyrroles
-
Protection of primary amine group is achieved by incorporating it into an N-substituted 2,5-dimethylpyrrole system.The method affords protection against strong bases and nucleophiles, heating with concentrated alkali, standard mineral acid work-up conditions, and various other reagents.Phenyl-, pyridil-, thiazolyl-, and alkyl-amines have been studied.All give trisubstituted pyrroles in high yield (>80percent) by reaction with hexane-2,5-dione.The pyrroles from the first three types are stable to storage; even the N-alkyl compounds can be used without difficulty.Regeneration of the amine group, by treatment with hydrxylamine hydrochloride, is efficient (80percent yield) with the phenyl, pyridyl, and alkyl compounds but less satisfactory (60 - 65percent generally but down to 25percent in two cases) with the thiazolyl derivatives.
- Bruekelman, Stephen P.,Leach, (Miss) Susan E.,Meakins, G. Denis,Tirel, Malcolm D.
-
p. 2801 - 2807
(2007/10/02)
-
- Protection of Primary Amines as N-Substituted 2,5-Dimethylpyrroles
-
Protection of a primary amine group against attack by organic or aqueous solutions of strong bases or nucleophiles is achieved by incorporation into an N-substituted 2,5-dimethylpyrrole system from which the amine group is regenerated by treatment with hydroxylamine hydrochloride.
- Breukelman, Stephen P.,Meakins, G. Denis,Tirel, Malcolm D.
-
p. 800 - 801
(2007/10/02)
-