- Dinuclear RuIIcomplexes with quinonoid bridges: Tuning the electrochemical and spectroscopic properties of redox-switchable NIR dyes through judicious bridge design
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Bridging quinonoid ligands are important platforms for generating metal-based switchable optoelectronic and magnetic materials. A possible sound way of influencing the properties of the aforementioned materials is to modify the direct metal-ligand interfa
- Beerhues, Julia,Chandra, Shubhadeep,Klenk, Sinja,Sarkar, Biprajit,Schweinfurth, David,Weisser, Fritz
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p. 8354 - 8366
(2020/07/10)
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- Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors
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A series of 2,5-substituted-1,4-benzoquinone (1-6) were prepared and structurally characterized by elemental analysis, IR spectra, 1H and 13C NMR spectra, and single crystal X-ray determination. The urease inhibitory activities of the compounds against H. pylori urease were studied. Among the compounds, 2,5-bis(2-morpholin-4-ylethylamino)-[1,4]benzoquinone (2) shows the most effective activity with IC50 value of 27.30 ± 2.17 μM. Docking simulation was performed to insert compound 2 into the crystal structure of H. pylori urease at the active site to determine the probable binding mode. As a result, compound 2 may be used as a potential urease inhibitor.
- You, Zhong-Lu,Xian, Dong-Mei,Zhang, Mei,Cheng, Xiao-Shan,Li, Xiao-Fang
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experimental part
p. 4889 - 4894
(2012/09/21)
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- THYMOQUINONE ANALOGS FOR THE TREATMENT OF PANCREATIC CANCER
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Analogs of thymoquinone, an active compound extracted from Nigellasativa (black seed oil) are 2,5-bis (alkyl/aryl amino) 1, 4-benzoquinones, are more potent than the naturally-occurring compound (e.g, have a lower IC50) in terms of inhibition o
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Page/Page column 5; 9
(2011/10/31)
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- Straightforward synthesis of substituted p-Quinones: Isolation of a key intermediate and use as a bridging ligand in a diruthenium complex
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(Figure Presented) Keep it simple: A new transamination method is reported for the synthesis of diamino-substituted p-quinones (see scheme). Asymmetrically substituted p-quinones are shown to be key intermediates in this reaction. The redox properties of these ligands are discussed and their utility in coordination and redox chemistry is shown with a representative example.
- Das, Hari Sankar,Weisser, Fritz,Schweinfurth, David,Su, Cheng-Yong,Bogani, Lapo,Fiedler, Jan,Sarkar, Biprajit
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supporting information; experimental part
p. 2977 - 2981
(2010/06/21)
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- Synthesis and biological evaluation of 2,5-bis(alkylamino)-1,4- benzoquinones
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A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9-58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, 1H- and 13/s
- Barbosa, Luiz Claudio Almeida,Pereira, Ulisses Alves,Maltha, Celia Regina Alvares,Teixeira, Robson Ricardo,Valente, Vania Maria Moreira,Ferreira, Jose Roberto Oliveira,Costa-Lotufo, Leticia Veras,Moraes, Manoel Odorico,Pessoa, Claudia
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experimental part
p. 5629 - 5643
(2010/12/24)
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- Structure-activity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer
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Purpose: Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoquinone (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the concentration of TQ required
- Banerjee, Sanjeev,Azmi, Asfar S.,Padhye, Subhash,Singh, Marjit W.,Baruah, Jubaraj B.,Philip, Philip A.,Sarkar, Fazlul H.,Mohammad, Ramzi M.
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scheme or table
p. 1146 - 1158
(2011/03/21)
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- Synthesis of 2,5-Diaminoquinones by one-pot copper-catalyzed aerobic oxidation of hydroquinones and addition reaction of amines
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The aerobic oxidation of various hydroquinones was achieved by using copper nanoparticles entrapped in aluminum oxyhydroxide [Cu/ AlO(OH)] at room temperature. Furthermore, 2,5diamino-1,4-benzoquinones were synthesized directly from hydroquinone and amines by a one-pot procedure consisting of the copper-catalyzed aerobic oxidation of hydroquinones and the double addition of amines to the resulting quinones.
- Kim, Sungjin,Kim, Daehwan,Park, Jaiwook
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experimental part
p. 2573 - 2578
(2009/12/29)
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