Asymmetric transfer hydrogenation of ketones using amino alcohol and monotosylated diamine derivatives of indane
A series of 1,2-amino alcohol and 1,2-monotosylated diamine derivatives of indane have been applied as ligands in the asymmetric ruthenium(II)-catalysed transfer hydrogenation reaction of a series of ketones. Of these, the cis-1-aminoindan-2-ol derivative gives some of the highest asymmetric inductions reported for any amino alcohol ligand in this application.
Palmer, Matthew J.,Kenny, Jennifer A.,Walsgrove, Tim,Kawamoto, Aparecida M.,Wills, Martin
p. 416 - 427
(2007/10/03)
Synthesis of enantiomerically pure cis- and trans-1,2- diaminoindanes
The four isomers of cis- and trans-1,2-diaminoindanes 5 and 11 were prepared in three steps and high enantiomeric excess by a key lipase- catalyzed selective transesterification of racemic cis-2-azido-1-indanol and trans-1-azido-2-indanol, respectively.
Bit, Christelle,Mitrochkine, Anton A.,Gil, Gerard,Pierrot, Marcel,Reglier, Marius
p. 3263 - 3273
(2007/10/03)
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