- Efficient Synthesis of tert-Butyl 2,4-Dialkynylated and 2-Alkynylated-4-Arylated-1H-Imidazole-1-Carboxylate via Regioselective Sonogashira Cross-Coupling Reaction
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An efficient regioselective cross-coupling reactions of tert-butyl 2,4-dibrominated-5-methyl-1H-imidazole-1-carboxylate is reported. This new synthetic route runs under simple and mild conditions and selectively gives an easy access to 2,4-dialkynylated a
- Jismy, Badr,El Qami, Abdelkarim,Jacquemin, Johan,Guillot, Regis,Tikad, Abdellatif,Abarbri, Mohamed
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p. 4495 - 4507
(2021/08/30)
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- ANTIVIRAL COMPOUNDS
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Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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Paragraph 0229
(2015/03/13)
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- Access to imidazo[1,2-a]imidazolin-2-ones and functionalization through Suzuki-Miyaura cross-coupling reactions
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We report herein a synthetic pathway to new 6(5)-bromo-5(6)- methylimidazo[1,2-a]imidazolin-2-ones. The synthetic potential of these scaffolds was demonstrated by displacing bromine by Suzuki-Miyaura cross-coupling reactions. A large panel of boronic acids (aryl, heteroaryl or vinyl) could easily be introduced, giving access to a large and diversified library of 6(5)-substituted 5(6)-methylimidazo[1,2-a]imidazolin-2-ones. A new route to 6(5)-bromo-5(6)-methylimidazo[1,2-a]imidazolin-2-ones have been developed. A novel and effective strategy of functionnalization of these scaffolds throught Suzuki-Miyaura cross coupling reactions is reported. Thanks to this methodology, a large panel of boronic acids were easily introduced, giving access to a diversified library of 6(5)-substituted 5(6)-methylimidazo[1, 2-a]imidazolin-2-ones. Copyright
- Grosse, Sandrine,Pillard, Christelle,Himbert, Franck,Massip, Stephane,Leger, Jean Michel,Jarry, Christian,Bernard, Philippe,Guillaumet, Gerald
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p. 4146 - 4155
(2013/07/11)
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