- "Double-concave" graphene: Permethoxylated hexa-peri- hexabenzocoronene and its cocrystals with hexafluorobenzene and fullerene
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Extremely nonplanar permethoxylated hexa-peri-hexabenzocoronene can be prepared by using a facile ferric chloride cyclodehydrogenation procedure. The combination of a rigid "double-concave" aromatic core with 18 flexible methoxy groups at the periphery ma
- Wang, Zhaohui,Doetz, Florian,Enkelmann, Volker,Muellen, Klaus
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- Space-conjugated organic molecule based on hexaarylbenzene skeleton and preparation and application thereof
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The invention belongs to the technical field of organic electronics, and discloses a space-conjugated organic molecule based on a hexaarylbenzene skeleton and preparation and application thereof. Thespace-conjugated organic molecular structure based on th
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Paragraph 0050; 0053; 0054
(2018/11/22)
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- Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels - Alder reactions
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Concise, efficient total syntheses of ningalin A (1), lamellarin O (2), lukianol A (3), and permethyl storniamide A (5) are detailed on the basis of a common heterocyclic azadiene Diels-Alder strategy (1,2,4,5-tetrazine → 1,2-diazine → pyrrole) ideally suited for construction of the densely functionalized pyrrole cores found in the three classes of marine natural products. Examination of the natural products and a number of synthetic intermediates revealed that some including lamellarin O (2) and lukianol A (3) exhibit modest cytotoxic activity against both wild-type and multidrug- resistant tumor cell lines. Fundamentally more important, a new class of agents including permethyl storniamide A (5) and its precursor 30, which lack inherent cytotoxic activity, are disclosed which reverse the multidrug- resistant (MDR) phenotype, resensitizing a human colon cancer cell line (HCT116/VM46) to vinblastine and doxorubicin at lower doses than the prototypical agent verapamil.
- Boger, Dale L.,Boyce, Christopher W.,Labroli, Marc A.,Sehon, Clark A.,Jin, Qing
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