- Amide derivative and application thereof in preparation of EP4 receptor antagonist
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The invention discloses a compound shown as a formula I. The compound can be used as an EP4 receptor antagonist of PGE2, inhibits enzyme and cell proliferation, and is used for treating diseases related to an EP4 receptor, including cancers, inflammatory diseases, pains and other indications.
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Paragraph 0077-0081; 0092-0097
(2021/04/07)
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- Indole derivatives as MCP-1 receptor antagonists
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The invention concerns pharmaceutically useful indoles of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, as well
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